The Upjohn Co.

Phillips Petroleum Company

Alcon, Inc.

Alcon Research, Ltd.

Alcon Manufacturing, Ltd.

Alcon Pharmaceuticals Ltd.

Research Corporation Technologies, Inc.

David W Stroman

John M Yanni

Gerald D Cagle

Robert L Abshire

Michael Miller Harpold

Masood A Chowhan

Alexander D Argoudelis

Kenneth C Appell

Celeste H McLean

Linda L Clark

Steven B Ellis

Juerg F Tschopp

James M Cregg

Wesley Wehsin Han

Thomas R Gingeras

Frank H Gaertner

L Wayne Schneider

Paul F Brust

George T Sperl

Mary J Hagenson

Thomas F Brodasky

Kathryn A Barr

Ronald D Klein

Mary Jane Hagenson

The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.

Compositions and methods for treating ophthalmic, octic, or nasal infections

Methods for treating otic infections

Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues.

Compositions containing moxifloxacin for treating otic infections

Method of treating otic infections with moxifloxacin compositions

Methods for treating ophthalmic, otic, or nasal infections

Method of treating ophthalmic infections with moxifloxacin compositions

Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues. The compositions and methods of the invention are particularly useful in the treatment of acute otitis externa infections and ophthalmic infections attributable to one or both of two newly identified Microbacterium species, and

Methods for treating otic and ophthalmic infections

Ophthalmic antibiotic compositions containing moxifloxacin

Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues. The compositions and methods of the invention are particularly useful in the treatment of acute otitis externa infections attributable to one or both of two newly identified Microbacterium species, and

Compositions and methods for treating otic, ophthalmic and nasal infections

Compositions and methods for treating ophthalmic and otic infections

Methods of treating or preventing ophthalmic, otic, and nasal infections and attendant inflammation are described. The methods utilize ophthalmic, otic, and nasal compositions containing a new class of antibiotics (e.g. trovafloxacin). The compositions also contain one or more anti-inflammatory agents (e.g. dexamethasone). The compositions are utilized to treat ophthalmic, otic, and nasal conditions by topically applying the compositions to the affected tissues.

Methods of treating ophthalmic, otic and nasal infections and attendant inflammation

Two novel linear DNA plasmids are described. Also, novel fragments of the plasmids containing the autonomous replication sequence (ARS), and thus capable of self-maintenance as extra chromosomal elements are provided. These novel DNA sequences of the present invention are useful in a vector for self-maintenance in Pichia pastoris and are also useful as plasmid vectors which can be shuttled between yeast and bacteria.

Pichia pastoris linear plasmids and DNA fragments thereof

Process for transforming yeast strains of the genus Pichia is disclosed. Novel yeast strains of the genus Pichia which can be transformed with recombinant DNA material are also disclosed. In addition, a method for isolating functional genes and other functional DNA sequences from yeast strains of the genus Pichia is described.

Transformation of yeasts of the genus pichia

Novel DNA sequences which are responsive to the presence of methanol, catabolite non-repressing carbon sources and carbon source starvation are provided. In addition, novel constructs including these DNA sequences, as well as transformed organisms therewith are provided. Processes for producing the DNA sequences and constructs of the invention are detailed. The production of polypeptide product under the control of the regulatory regions of the invention is demonstrated.

Regulatory region for heterologous gene expression in yeast

A method for isolating and cloning methanol inducible genes from Pichia is taught. The regulatory regions are useful for the methanol regulated expression of heterologous genes.

Methanol inducible genes obtained from pichia and methods of use

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Irving, TX, United States of America

David W Stroman