Merck + Co., Inc.

David W Smith

Leonardus H T Van Der Ploeg

Hui Zheng

Howard Y Chen

Myrna E Trumbauer

Robert P Heavens

Gurparlash Singh

Dalip J S Sirinathsinghji

Aurawan Vongs

Transgenic non-human mammals which express in their brains a nucleic acid construct comprising a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine. These transgenic non-human mammals can be assays systems for determining compounds which are effective in modulating production of human amyloid precursor protein in brain and in isolated neuronal cells. Specifically exemplified are transgenic mice whose genome comprises a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine operably linked to a Thy-1 promoter. The mice are shown to produce the APP-FAD variant in their brains by mRNA and protein assays.

Transgenic mouse expressing a familial form of human amyloid precursor protein

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Harlow, United Kingdom

David W Smith