3m Innovative Properties Company

Minnesota Mining and Manufacturing Company

Kindeva Drug Delivery, L.p.

3m Company

David W Schultz

Daniel C Duan

James S Stefely

Chester L Leach

Robert K Schultz

Robert A Moris

Craig Allen Perman

Luke E Schallinger

Stephen W Stein

Philip A Jinks

Martin J Oliver

William F Hansen

John K Simons

The present disclosure provides a method of preparing a pharmaceutical composition. The method includes transferring a predetermined quantity of an excipient mixture from a second vessel to a first vessel. The excipient mixture transferred from the second vessel includes a liquid-state second quantity of a hydrofluoroalkane propellant and a first solubilized excipient comprising a low-molecular weight poly(ethylene oxide) polymer. The method further includes contacting at least one pharmaceutically-active compound with the excipient mixture under conditions that facilitate forming an intermixture comprising the propellant, the polymer, and the compound. Before transferring the excipient mixture, the first vessel contains a vapor-phase first quantity of the hydrofluoroalkane propellant and an effective amount of the at least one pharmaceutically-active compound.

Method of preparing a pharmaceutical composition

Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula &#x2014;[X&#x2014;R&#x2014;C(O)]&#x2014; wherein each Ris an independently selected organic group that links the &#x2014;X&#x2014; group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.

Biocompatible compounds for sustained release pharmaceutical drug delivery systems

Pharmaceutical suspension aerosol formulations containing a therapeutically effective amount of a drug and HFC 134a, HFC 227, or a mixture thereof.

Suspension aerosol formulations

Pharmaceutical suspension aerosol formulations containing a therapeutically effective amount of a drug and HFC 134 , HFC 227, or a mixture thereof.

Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula &mdash;&lsqb;X&mdash;R &mdash;C(O)&rsqb;&mdash; wherein each R is an independently selected organic group that links the &mdash;X&mdash; group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.

Medicinal aerosol solution formulation with biocompatible polymer

Pharmaceutical solution aerosol formulations comprising beclomethasone 17,21 dipropionate, ethanol, and a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, and a mixture thereof.

Method of forming conductive lines

Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula --[X--R.sup.1 --C(O)]-- wherein each R.sup.1 is an independently selected organic group that links the --X-- group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.

Biocompatible compounds for pharmaceutical drug delivery systems

A medicinal aerosol formulation containing a particulate drug and a diol/diacid condensate as a dispersing aid.

Aerosol formulation containing a diol-diacid derived dispersing aid

Beclomethasone solution aerosol formulations

A medicinal aerosol formulation containing a particulate drug and a dispersing aid derived from a hydroxyacid, a mercapto acid, or an amino acid.

Growing community of inventors

Pine Springs, MN, United States of America

David W Schultz