University of Washington

Fred Hutchinson Cancer Center

Oricula Therapeutics LLC

Fred Hutchinson Cancer Research Center

David W Raible

Julian Simon

Edwin W Rubel

Graham Johnson

Peter C Meltzer

Qin Jiang

Xinchao Chen

R Jason Herr

Weishi Miao

Sarwat Chowdhury

Kelly N Owens

Mario D Gonzalez

Felipe Santos

Henry C Ou

Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

Compounds and methods for preventing or treating sensory hair cell death

Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

Compounds and methods for preventing, treating and/or protecting against sensory hair cell death

The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.

Compounds that protect against sensory hair cell death

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Seattle, WA, United States of America

David W Raible