Minnesota Mining and Manufacturing Company

University of Washington

David W Osten

Hatim M Carim

James B Callis

John W Louks

Ronald P Swanson

Steven J Lenius

Mark A Berman

Eugen Will

Joseph W Petrin

Anatoly Akselrod

Bradford L Blan

Michael R Arneson

James B Cysewski

A method for predicting a property of biological matter, such as biological fluid, containing water, in a dynamic condition where the biological fluid may be approximated to contain two compartments where one compartment has a proportionally larger or smaller amount of water than the other compartment having the property of interest. The method involves establishing a training set in the near-infrared (NIR) region with independent quantification of the property of the fluid using known techniques. The training set is mathematically analyzed according to a correlation developed by regression analysis after employment of a pre-processing technique such as a multiple derivative transformation of spectra or a ratioing of two wavelengths in the spectra. The result is a mathematical transformation equation which quantitatively relates spectral intensities at specific wavelengths to the property of interest. This transformation equation may be applied to unknown samples so as to predict their properties, thereby eliminating need for the reference method except for validation or recalibration. The method provides rapid and accurate prediction of the property of the unknown sample, which may be the property of hematocrit or hemoglobin concentration in whole animal blood. Other analyses of properties in the biological fluid such as oxygen saturation in hemoglobin in whole animal blood may be included in the mathematical analysis to further refine the prediction of the property of interest. Also, a loop from the patient is disclosed for the purpose of monitoring the property of interest nearly simultaneously with changes in that property of interest.

Characterizing biological matter in a dynamic condition using near

A method is provided for predicting a property of a matter of biological origin, such as biological fluid, containing water, in a dynamic condition where the biological fluid may be approximated to contain two compartments where one compartment has a proportionally larger or smaller amount of water than the other compartment having the property of interest. The method involves establishing a training set in the near-infrared (NIR) region with independent quantification of the property of the fluid using known techniques. The training set is mathematically analyzed according to a correlation developed by regression analysis after employment of a pre-processing technique such as a multiple derivative transformation of spectra or a ratioing of two wavelengths in the spectra. The result is a mathematical transformation equation which quantitatively relates spectral intensities at specific wavelengths to the property of interest. This transformation equation may be applied to unknown samples so as to predict their properties, thereby eliminating need for the reference method except for validation or recalibration. The method provides rapid and accurate prediction of the property of the unknown sample, which may be the property of hematocrit or hemoglobin concentration in whole animal blood. Other analyses of properties in the biological fluid such as oxygen saturation in hemoglobin in whole animal blood may be included in the mathematical analysis to further refine the prediction of the property of interest. Also, a loop from the patient is disclosed for the purpose of monitoring the property of interest nearly simultaneously with changes in that property of interest.

A personal, biometric authentication system is disclosed. The system can be used for controlling access to equipment or physical facilities. The system employs the combination of a unique, inherently specific biometric parameter recognized and compared with stored data and at least one non-specific biometric parameter of a physiological characteristic recognized and compared with physiological norms. Positive comparison results in authentication of an individual that is not incapacitated, dismembered, or deceased.

Biometric, personal authentication system

A method for predicting a property of a matter of biological origin, such as biological fluid, containing water, where the biological matter may be approximated to contain two compartments where one compartment has a proportionally larger or smaller amount of water than the other compartment having the property of interest. The method establishes a training set in the near-infrared (NIR) region with independent quantification of the property of the matter using known techniques. The training set is mathematically analyzed according to a correlation developed by regression analysis after employment of a ratio pre-processing technique. The result is a mathematical transformation equation which quantitatively relates spectral intensities at specific wavelengths to the property of interest. This transformation equation may be applied to unknown samples so as to predict their properties, thereby eliminating need for the reference method except for validation or recalibration. There is rapid and accurate prediction of the property of the unknown sample, which may be the property of hematocrit or hemoglobin concentration in whole animal blood.

Method for the prediction of properties of biological matter by analysis

An open tube apparatus and method for continuously producing a rotating elongate strip of material are disclosed. An extrusion die continuously extrudes flowable material to form an open tube with a central longitudinal cavity and a transport mechanism includes a plurality of drive rollers which engage and pull the tube downline. A driver rotates the extrusion die and transport mechanism. A tube cutter, which is offset at an angle with respect to the downline direction and defines the open end of the tube, cuts the tube into a continuous elongate web of the desired width as the tube moves downline. An air seal seals the tube cavity to prevent air from escaping through the open end of the cavity, and a tube pressurizer controls air pressure in the central longitudinal cavity of the tube to expand the tube laterally outwardly.

Growing community of inventors

Saint Paul, MN, United States of America

David W Osten