Southern Research Institute

David W Mason

Thomas R Tice

Amanda McRae-McFarlane

Deborah L Dillon

Annica B Dahlstrom

Richard J Holl

Annica Dahlstromm

Alan H Dean

The present invention relates to polymeric microspheres as injectable, drug-delivery vehicles for use to deliver bioactive agents to sites within the central nervous system, and for the stimulation of nerve fiber growth by implanting such microspheres within the central nervous system of a patient. Microspheres of less than 45 &mgr;m, preferably less than about 20 &mgr;m, and preferably about 0.1 &mgr;m to about 10 &mgr;m in mean diameter according to the present invention are also selectively taken-up and into astrocytes when delivered directly into the nervous tissues.

Microcapsules for administration of neuroactive agents

A composition, comprising an agent, a carrier admixed with the agent to form a mixture, and a film-forming polymer coating around the mixture which is insoluble in a selected solvent. A biocidal composition, comprising a biocide, such as an aldehyde, a carrier admixed with the aldehyde to form a mixture, and a film-forming polymer coating around the mixture which is insoluble in a selected solvent. The composition of the invention further comprising an acidifying agent admixed with the aldehyde. The composition of the invention and an activator. An article of manufacture, comprising the composition of the invention contained inside a fluid-permeable mesh bag. A method of making a biocidal composition, comprising admixing a carrier with an aldehyde to form a mixture, and coating the mixture with a film-forming polymer coating which is insoluble in a selected solvent. A method of making a biocidal article of manufacture, comprising enclosing within a fluid-permeable mesh bag the biocidal composition of the invention and an activator. A method of making a biocidal composition, comprising contacting the biocidal composition of the invention with the selected solvent and adding an activator to the composition in the solvent.

Encapsulated biocidal preparation

The present invention relates to polymeric microspheres as injectable, drug-delivery systems for use to deliver bioactive agents to sites within the central nervous system, and for the stimulation of nerve fiber growth by implanting such microspheres within the central nervous system of a patient.

Method for stimulating nerve fiber growth

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Birmingham, AL, United States of America

David W Mason