The University of British Columbia

Qlt Phototherapeutics, Inc.

Quadra Logic Technologies, Inc.

Qlt Phototherapeutices Inc.

David W Hunt

Julia G Levy

Anna M Richter

Agnes How-Ching Chan

Guillermo O Simkin

Modestus O Obochi

David H Dolphin

Ethan D Sternberg

Ashok Jain

Ronald Erwin Boch

Elizabeth M Waterfield

Simon Leong

Martin Renke

New compounds useful in photodynamic therapy are of the formula ##STR1## and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof

Ethylene glycol esters as photoactive agents

Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen. This effect occurs at ambient light levels.

Green porphyrins as immunomodulators

Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen, as well as to interfere with intercellular communication. These effects occur in the absence of radiation absorbed by the green porphyrin.

Multiple sclerosis and rheumatoid arthritis can be treated effectively using photodynamic therapy. In this protocol, a photoactive compound is administered, allowed to distribute in the effected subject, and the subject is then irradiated to activate the photoactive compound. Alternatively, the blood of a subject to be treated can be subjected to PDT extracorporeally. In the case of rheumatoid arthritis, localized treatment at the joints may also be employed.

Method for selectively reducing activated leukocyte cell population

Growing community of inventors

White Rock, Canada

David W Hunt