Uop Lcc

Orochem Technologies, Inc.

Kazmira LLC

Alliedsignal Inc.

Saint-gobain Performance Plastics Corporation

Dorf Ketal Chemicals, LLC

David W House

Ray V Scott, Jr

Anil Rajaram Oroskar

Gautham Anil Oroskar

Faridedin Adel

Asha Anil Oroskar

Mark J Gattuso

Praneeth Dayanthe Edirisinghe

Xinjie Chen

William M Baumann

Kunal Gulati

Raymond John Swedo

Thomas P Malloy

Dusan J Engel

Mark A Halter

Deepak Sharma

Santi Kulprathipanja

Peter R Pujado

David C DeCoster

Paul R Kurek

Pawel Czubarow

Gwo S Swei

Olivier Guiselin

Stephen C Lapin

Ilya L Rushkin

Feng Peng

Rakesh Vikraman Nair Rema

Omkar M Kulkarni

Kashif Shan

Pulak Sharma

Justin Fulford

Alice M Havill

Rajesh Kumar Gupta

Michelle Chen

A method of removing THC and/or THCA from a mixture is provided, the mixture including at least one other cannabinoid. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.3 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Process for removing THC from cannabinoids

A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp andleaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from theplant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Process for separating a constituent/cannabinoid using a chromatographic resin

The present invention relates generally to improved methods for the extraction and isolation of cannabinoids from hemp. More particularly, the present invention relates to a series of extraction and isolation processes employed to selectively enhance recovery of non-psychoactive cannabinoids and the like, frommaterials and extracts, while removing undesirable naturally occurring components that may be present including colorants, carbohydrates, sugars and waxes, and the like, as well as contaminants that may be present in source materials including bactericides, fungicides, insecticides, plant growth regulators, environmental pollutants, and processing aids, and the like. The present invention further relates to an isolate obtained using a series of extraction and isolation processes that has extremely high cannabinoid content present in a stable, flowable liquid form that is essentially free of detectable levels of psychoactive cannabinol components.

CBX extraction-isolation process

A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from the dried hemp andleaves can use a continuous simulated moving bed process and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from theplant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Process for purification and separation of cannabinoids, from dried hemp and cannabis leaves

Disclosed is a method for purification and separation of cannabinoids, specifically cannabidiol and tetrahydrocannabinol, from the dried hemp andleaves using a combination of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, a continuous simulated moving bed process, polishing, and crystallization to separate cannabinoids from tetrahydrocannabinol and to provide phytocannabinoid rich oil and cannabidiol isolate. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Disclosed is a process for the production of d-tagatose from lactose after acid hydrolysis to provide a hydrolysate having 1 equiv of d-glucose and 1 equiv of d-galactose for each unit of lactose converted. More particularly, the invention relates to a process for the isomerization of d-galactose to d-tagatose and the use of a simplified separation scheme based on simulated moving bed (SMB) separation. The isomerization of d-galactose to d-tagatose is carried out in the presence of calcium oxide or calcium hydroxide. The process is useful for providing a simplified processing route to providing pure d-tagatose and glucose as two products from lactose hydrolysate. In an alternate embodiment, a process is disclosed for the production of d-tagatose from fermented lactose hydrolysate to provide a crystallized d-tagatose product. D-tagatose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant.

Tagatose production using simulated moving bed separation

Disclosed is a process and an adsorbent for the separation of ethanol associated oxygenates from a dilute mixture of ethanol and associated oxygenates in water in the presence of organic compounds derived from a biofermentation process. After pretreatment, the separation is carried out in a simulated moving bed adsorption system employing an stationary phase adsorbent comprising fluorinated carbon or modified C18 silica gel selective for the adsorption of ethanol and associated oxygenates, such as 2,3-butanediol, with a mobile phase desorbent selected from the group consisting of methanol, ethanol, propanol, and methyl tertiary butyl ether. The process is useful for removing water from dilute aqueous mixtures of organic compounds comprising ethanol in dilute concentration in water and produced by fermentation, biomass extraction, biocatalytic and enzymatic processes which are not economically recoverable by conventional distillation methods.

Process and adsorbent for separating ethanol and associated oxygenates from a biofermentation system

A composite material includes a polyimide matrix material and an exfoliated graphite material dispersed within the polyimide matrix material. The composite material exhibits a Thermal Stability Index of at least about 20 and has a particle distribution in which 90% of the particles have a particle size not greater than 500 micrometers.

Thermally stable composite material formed of polyimide

A process for oxygenating organic substrates such as aliphatic hydrocarbons has been developed. The process involves contacting the organic substrate with oxygen in the presence of a bicyclo imide promoter and a metal co-catalyst. The process is preferably carried out using sulfolane as the solvent. Optionally, the oxygenated product can be hydrogenated to give the corresponding alcohol which can optionally in turn be dehydrated to provide the corresponding olefin.

Conversion of organic substrates to oxygenates or olefins using a bicyclo imide promoter

Curing agents for epoxy-based polymers

Certain secondary aliphatic diamines are excellent chain extenders in the formation of polyurethanes, polyurea-polyurethane hybrids, and polyurea polymers, both elastomers and coatings, from both monomeric polyisocyanates and isocyanate-terminated prepolymers using the high-pressure impingement mixing reaction technique. These diamines include 1,4-di(alkylamino)cyclohexanes, 1-methyl-2,4-di(alkylamino)-3,5-dialkylcyclohexanes, N,N&prime;-dialkyl isophoronediamine, 1,3-di(1&prime;methyl-1&prime;-alkylaminoethyl)benzene, and 1,6-di(alkylamino)hexane. These chain extenders may be used alone or in combination with other polyamines and with polyols. A broad spectrum of polymeric materials can be formed with a range of diverse properties.

Secondary aliphatic diamines as curing agents for polyurethanes and polyureas prepared using high-pressure impingement mixing

Carbonyl compounds (e.g. acetone and acetaldehyde) are often present as impurities in oxygenated organic liquids such as acetic acid made by the carbonylation of methanol or in phenol produced by the oxidation of cumene. These impurities can render petrochemical products unsuitable for long-term storage or otherwise adversely affect downstream processing operations. It has now been found that detrimental carbonyl impurities can be easily removed from oxygenated organic liquids by contact with resins having amine functional groups.

Adsorptive removal of carbonyl impurities from oxygenated organic liquids

A chromatographic process for separating racemic mixtures using a set of chiral stationary phases based on yohimbine and its derivatives has been developed. In particular, the hydroxyl functionality of yohimbine and its analogs is covalently bonded via a urethane linkage to a polymethylenesilyl chain attached to the bound hydroxyl groups of a refractory inorganic oxide by Si&mdash;O bonds. The resulting chiral stationary phases have multiple chiral recognition sites and can be used with a broad spectrum of materials as eluents without leaching.

Chromatographic process using a chiral stationary phase based on yohimbine

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Arlington Heights, IL, United States of America

David W House