Qlt Inc.

Dermira (canada), Inc.

University of British Columbia

Other

Sunnybrook and Women's College and Health Science Centre

Qlt, Inc. and

David W C Hunt

Anna M Richter

Ronald Erwin Boch

Julia G Levy

Timothy Scott Daynard

Geoffrey C Winters

David H Dolphin

Ethan D Sternberg

Guillermo O Simkin

Elizabeth M Waterfield

Ashok Jain

Peter Lutwyche

John Robert North

Shoukat Dedhar

Greg Hannigan

Andrew Norman Tovey

Jean-Marie Houle

Patrick Mark Curry

Ladan Fazli

Jing-Song Tao

Alain H Curaudeau

Herma C Neyndorff

Ethan Sternberg

Jain Ashok

Andrew N Tovey

This invention is directed to analogs of 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA) and their use in the treatment of dermatological disorders or conditions characterized by sebaceous gland hyperactivity, such as acne and oily skin, and other dermatological disorders and conditions. This invention is also directed to pharmaceutical compositions comprising analogs of TOFA and a pharmaceutically acceptable excipient for dermatological or oral administration.

TOFA analogs useful in treating dermatological disorders or conditions

This invention is directed to analogs of 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA) and their use in the treatment of dermatological disorders or conditions characterized by sebaceous gland hyperactivity, such as acne and oily skin, and other dermatological disorders and conditions. This invention is also directed to pharmaceutical compositions comprising analogs of TOFA and a pharmaceutically acceptable excipient for dermatological or oral administration. Formula (I) 

Inhibitors of integrin-linked kinase (ILK) are used in the treatment of inflammatory disease, including cutaneous inflammatory diseases, such as psoriasis, scleroderma, systemic lupus erythematosus and atopic dermatitis.

Treatment of inflammatory diseases including psoriasis

Immuno-adjuvant photodynamic therapy to treat and prevent metastatic cancer is effected using photosensitizers in combination with immuno-adjuvants to destroy metastatic tumor cells.

Immuno-adjuvant PDT treatment of metastatic tumors

Photodynamic therapy (PDT) is used to stimulate and/or restore hair growth in areas of hair loss. Methods and compositions relating to PDT treatment for alopecia are disclosed. In light of PDT use to remove unwanted hair by inactivating or destroying hair follicles or destroying the tissue feeding the hair follicles, such methods and compositions relate to a surprising and unexpected discovery. PDT permits a means to treat conditions relating to hair loss such as androgenic alopecia, alopecia areata and drug-induced alopecia.

Photodynamic therapy for the treatment of hair loss

New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomersand the metallated and/or labeled and/or conjugated forms thereof

Ethylene glycol esters as photoactive agents

Growing community of inventors

Surrey, Canada

David W C Hunt