Roche Diagnostics Operations, Inc.

Roche Operations Ltd.

Other

Roche Diagnostics Gmbh

Roche Diabetes Care, Inc.

Corange International Limited

F. Hoffmann-la Roche Ag

David W Burke

Terry Allen Beaty

Lance Scott Kuhn

Vladimir Svetnik

Michael Marquant

Nigel A Surridge

Eric R Diebold

Michael J Celentano

James F Maxwell

Jiaxiong Jason Ho

R Dale Delk

Henning Groll

Brian A Heald

Robert Kitchel Earl

Michael Fritz

Dan Mosoiu

William F Crismore

Udo Zapf

Chris Wilsey

Richard J Bodensteiner

Daniel R McMinn

Raghbir Singh Bhullar

Christopher Douglas Wilsey

Harvey B Buck, Jr

Brian S Hill

Timothy L Beck

Paul Douglas Walling

Janette Elaine Allen

James L Maxwell

Lance S Khun

Lance S Kuhn

Daniel R Mcminn

A method is disclosed for determining analyte concentration that includes applying a first electrical potential excitation pulse to a body fluid sample in an analyte sensor, and a first current response of the body fluid sample to the first pulse is measured. A second excitation pulse is applied to the body fluid sample in the analyte sensor, and a second current response of the body fluid sample to the second pulse is measured. An analyte level in the body fluid sample is determined by compensating for sources of error based on the first current response to the first pulse.

Systems and methods to compensate for sources of error during electrochemical testing

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

Method for determining whether a disposable, dry regent, electrochemical test strip is unsuitable for use

System and method for analyte measurement

System and method for analyte measurement using dose sufficiency electrodes

Transparent lamp fixture and illumination module

The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted. In one embodiment, a first test strip comprises: a first measurement electrode connectable to a test meter; a first trace loop with a first associated resistance, where the first trace loop is connectable to the test meter; and a second trace loop with a second associated resistance, where the second trace loop is connectable to the test meter. The test meter is adapted to: receive the first test strip; connect to the first measurement electrode, the first trace loop, and the second trace loop; and obtain a first resistance ratio by comparing the first and second associated resistances.

System and method for coding information on a biosensor test strip

System and method for determining an abused sensor during analyte measurement

Methods of manufacturing test strips are disclosed. Embodiments include laminating a two piece covering layer over a substrate with a series of cavities, wherein the two pieces are separated by a gap, the gap forming a vent opening for the cavities. Other embodiments include covering the sample receiving chamber with a cover thinner than the cover covering the body of the test strip, the thicker body cover absorbing more force than the chamber cover to reduce the possibility of adhesives squeezing out from under the chamber cover. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.

Test strip with slot vent opening

Medicinal fluid delivery systems and methods for priming the same are disclosed. The systems may be configured to measure an electro-transmissive quality of a medicinal fluid when: medicinal fluid is dispensed into a fluid delivery path, a proximal end of the fluid delivery path is in contact with a first electrode, and the distal end of the fluid delivery path is in contact with a second electrode. Methods for priming medicinal fluid delivery systems may include dispensing a medicinal fluid through a fluid delivery path, sensing an electro-transmissive quality of the medicinal fluid, and determining that the fluid delivery path is full based on the electro-transmissive quality.

Medicinal fluid delivery systems and methods for priming the same

A test strip with a covering layer having a novel slot. The slot divides the inventive covering layer into two parts and provides a vent opening that allows air to escape as fluid enters a cavity or sample receiving chamber formed in the test strip. In preferred embodiments, the covering layer is clear such that the user can see through it and the slot doubles as a 'fill line.' The user can thus watch the fluid sample enter the test strip, progress through the capillary cavity, and then stop at the slot or fill-line. This provides positive assurance to the user that the sample size is sufficient and the test strip has been filled properly. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.

Control and calibration solutions are described that provide control and calibration data that is recognized by a test meter allowing the meter to segregate the control and calibration data from regular test data. Recognition and segregation of the control and calibration data can occur automatically with no additional input from the meter's user. Methods for use of the solutions are also provided.

Control and calibration solutions and methods for their use

An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a 'fill to here' line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called 'dose hesitation'.

Electrochemical biosensor test strip

Growing community of inventors

Carmel, IN, United States of America

David W Burke