Amgen Inc.

David W Brankow

Shaw-Fen Sylvia Hu

Chadwick Terence King

Thomas Charles Boone

Colin V Gegg

Hsieng Sen Lu

Cen Xu

Licheng Shi

Jean Marie Gudas

Thomas C Boone

Jr Gegg Colin V

Colin V Gegg Jr

Jr Colin V Gegg

Chadwick T King

Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

Human CGRP receptor binding proteins

The invention concerns eukaryotic cells useful in protein expression comprising (a) an inserted nucleic acid encoding a cyclin D gene product and (b) an inserted nucleic acid encoding a protein of interest, wherein the cyclin D gene product and the protein of interest are expressed in the cell. The invention also concerns a process for producing a protein of interest, which comprises (a) inserting into a eukaryotic cell a nucleic acid encoding a cyclin D gene product and a nucleic acid encoding a protein of interest; (b) culturing the cell under conditions permitting the expression of the protein of interest; and (c) isolating the protein of interest. The cells are preferably mammalian, with CHO cells most preferred. The cyclin D gene product is preferably of human origin. Suitable proteins of interest include erythropoietin (EPO), osteoprotegerin (OPG), OPG-Fc, leptin, Fc-leptin, and Novel Erythropoiesis Stimulating Protein (NESP).

Overexpressing cyclin D 1 in a eukaryotic cell line

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Northridge, CA, United States of America

David W Brankow