Johns Hopkins University

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

David W Blodgett

Scott M Hendrickson

Jeremiah J Wathen

Michael P McLoughlin

Donald D Duncan

Nicole E Steiner

Mark A Chevillet

Carissa L Rodriguez

Austen T Lefebvre

Eyal Bar-Kochba

Jerry A Krill

Nicholas D Beser

Michael W Roth

Kevin C Baldwin

Philip J McNally

Kevin C Wolfe

Jared M Wormley

Michael J Fitch

Tomasz M Kott

Charles H Lange

Vincent R Pagan

David L Brody

Max R Basescu

Adam Cohen

Clare W Lau

An intracranial access device includes a housing having an operator-facing side and a patient-facing side and an opening therethrough extending from the operator-facing side to the patient-facing side. The device further includes at least one fastener configured to secure the device to a cranium of a patient. The device further includes a drill mounted to a surface of the housing and a cauterizer. The device may further include a number of sensors arranged on the patient-facing side of the housing and configured to identify a hemorrhage location.

Automated cranial burr hole device and method

A system includes first and second radiation sources, first and second detectors, a signal digitizer, a controller, and an analyzer. The first and second radiation sources generate respective first and second beams of radiation to irradiate a target. The first beam and second beams each include a first wavelength operated at a first modulation frequency and a second wavelength operated at a second modulation frequency. The first and second detectors each include a photo-sensitive element that generate first or second detection signals, a Faraday shielding enclosure, a signal amplifier, and a frequency mixer to frequency-adjust the first or second detection signals. The controller provides timing information to inform an activation scheme of the first and second radiation sources and corresponding radiation detection events at the first and second detectors. The analyzer analyzes the first and second detection signals and determines at least amplitude and phase information of the scattered radiation.

High sensitivity frequency-domain spectroscopy system

A holographic imaging system may include an optical source configured to output a source beam and a splitter configured to split the source beam into a reference beam and an object beam that may be incident on a target to form a scattered object beam. The system may also include a combiner configured to combine the filtered scattered object beam with the reference beam to form an interference beam, an imaging array configured to receive the interference beam and generate frames of raw holographic data based on measurements of the interference beam over time, and an image data processor. The image data processor may be configured to receive the frames of raw holographic data from the imaging array, remove data components within the frames that are associated with the particle motion having a motion frequency that is less than a movement frequency threshold to form conditioned raw holographic data, and generate an image based on the conditioned raw holographic data.

Coherent optical holographic imaging

A holographic imaging system may include an optical source configured to output a source beam, a splitter configured to split the source beam into a reference beam and an object beam that is incident on a target to form a scattered object beam, and a pre-filter comprising a telecentric lens and a spatial filter. The pre-filter may be configured to receive the scattered object beam and filter diffuse light from the scattered object beam to form a filtered scattered object beam. The system may also include a combiner configured to combine the filtered scattered object beam with the reference beam to form an interference beam, and an imaging array configured to receive the interference beam and generate raw holographic data based on the interference beam.

An optical receiver is provided that includes an array of photoreceivers. Each photoreceiver may be configured to receive a respective portion of a speckle pattern generated by interaction between an object beam and a scattering medium and each photoreceiver may be configured to generate respective electrical detection signals for provision to processing circuitry for summing of the electrical detection signals. A photoreceiver may include a collector, first detector and second detectors, and first and second optical splitters. The photoreceiver may be configured to generate a first electrical detection signal and a second electrical detection signal based on a received portion of the speckle pattern.

Multi-channel coherent detection

A method for particle velocity measurement may include transmitting an optical beam from an optical source, splitting the optical beam into a first beam and a second beam where the first beam and the second beam each have different polarizations, directing the first beam and the second beam toward an object, and determining a velocity of the object based on receiving the first and second beams reflected from the object.

Robust particle velocity measurement

Example apparatuses and methods relating to imaging systems are provided. An example imaging system may include an optical source configured to generate an optical beam, a beam splitter configured to split the optical beam into a reference beam and an object beam, and a beam combiner configured to route a combined beam with reference beam and object beam components along a common path into a target medium. In this regard, the target medium may act upon the combined beam to form a common path interference beam. The example imaging system may further include an imaging sensor configured to receive the common path interference beam and generate common path interference beam data associated with the common path interference beam, and an image data processor configured to analyze the common path interference beam data to generate image data describing the target medium.

Coherent optical imaging for detecting neural signatures and medical imaging applications using common-path coherent optical techniques

An example imaging system may include a spatial light modulator and a coherent optical receiver. The spatial light modulator may be configured to receive an optical input wave and perform wavefront shaping on the optical input wave to output a shaped wave. The coherent optical receiver may include an optical local oscillator, an optical beam splitter, an optical detector, and processing circuitry. The optical detector may be configured to receive a mixed wave from the optical beam splitter that is based on the mixing of a local oscillator wave with a scattering medium output wave that at least initially comprises a speckle pattern formed by the shaped wave interacting with a scattering medium. The processing circuitry may be configured to perform coherent detection on the mixed wave to extract optical amplitude and phase information, and provide an error signal as feedback to the spatial light modulator for performing iterative wavefront shaping.

Wavefront shaping with coherent optical sensing

A neural imaging system may include an imaging array, an image data processor operably coupled to the imaging array to process image data received from the imaging array, and a beam angle separator disposed between the imaging array and an object being imaged. The beam angle separator may be configured to separate an object beam reflected from the object being imaged into a plurality of reference beams each having different angular separation with respect to the object beam. The image data processor may be configured to generate image data of the object for each one of the reference beams to correspond to a respective different depth within the object.

Coherent optical imaging for detecting neural signatures and medical imaging applications using holographic imaging techniques

Disclosed is a system for a 3-dimensional display that includes at least one eyepiece having first and second eyepiece sockets, having a first display contained in said first eyepiece socket associated with a first eye, two eye cameras mounted such that a first eye camera tracks eye reference points of said first eye and a second eye camera tracks reference points of a second eye, a processor for providing overall control of said at least one eyepiece; a second display; and a main processor; signals are transmitted between said main processor and said at least one eyepiece, wherein said two eye cameras track said reference points, said eyepiece transceiver transmits said reference points to said main processor via said main transceiver, said main processor generates image data based on said reference points and transmits said image data to said displays to produce a 3-dimensional image.

System and method for 3-dimensional display of image data

A means of assessing the internal structure of teeth based upon use of high frequency, highly localized ultrasound (acoustic waves) generated by a short laser pulse is presented. In contrast to traditional contact transducer methods, laser-generated ultrasound is non-contact and non-destructive in nature and requires no special tooth surface preparation. Optical interferometric detection of ultrasound provides a complementary non-destructive, non-contact means for obtaining data with a very small detection footprint. The combination of laser-generated ultrasound and optical interferometric detection allows for in-vivo diagnostics of tooth health that is sensitive to the enamel/dentin, dentin/pulp, and dentin/cementum interfaces as well as a region of dead tracts in the dentin within a tooth.

Assessment of tooth structure using laser based ultrasonics

A method for selecting trees for harvest according to a predetermined criterion is provided which includes at least the steps of applying a vibrative member to the tree, vibrating the vibrative member, determining the resonance properties of the vibrative member, calculating an observed quality factor associated with the vibrative member vibrations, and, comparing the observed quality factor with a predetermined relationship between the quality factor and the tree selection criterion. A portable tree probe, suitable for field use, is also provided.

Method and apparatus for selecting trees for harvest

Vanadium dioxide (VO.sub.2) based infrared spatial light modulators (SLM) in four embodiments are disclosed:

Growing community of inventors

Ellicott City, MD, United States of America

David W Blodgett