Laboratorios Del Dr. Esteve S.a.

David Vano-Domenech

Jordi Corbera-Arjona

Daniel Martinez-Olmo

Jordi Frigola-Constansa

Joerg Holenz

Maria Neus Mesquida-Estevez

The present invention relates to compounds having pharmacological activity towards the sigma (&#x3c3;) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis. 

4,5,6,7-tetrahydrobenzo[B]thiophene derivatives and their use as sigma receptor ligands

The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals. 

Sigma receptor compounds

The present invention relates to compounds having pharmacological activity towards the sigma (&#x3c3;) receptor, and more particularly to some 4,5,6,7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis. 

4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands

New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), where Rrepresents an ORradical, where Rrepresents a radical derived from a saturated hydrocarbon, with a linear or branched chain of 1 to 4 carbon atoms, and Rrepresents a phenyl radical substituted at least by one cyan radical (&#x2014;C&#x2261;N), or a radical of a heteroaromatic ring of 5 or 6 members substituted at least by one cyan radical (&#x2014;C&#x2261;N); and their physiologically acceptable salts, are useful for application in human and/or veterinary therapeutics as sedatives, anticonvulsants, hypnotics and general anaesthetics 

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David Vano-Domenech