Air Products and Chemicals, Inc.

Centocor, Inc.

Hahnemann University

David V Woo

Frank Kenneth Schweighardt

Zenon Steplewski

Jeffrey A Mattis

A radiotherapeutic immunoconjugate comprising a tumor specific monoclonal antibody, or fragment thereof, and an Auger electron emitting radionuclide, wherein the tumor specific monoclonal antibody or fragment is capable of tumor nucleus localization of the radionuclide and method of using it is disclosed. The radiotherapeutic immunoconjugate is administered in a therapeutically effective amount to patients having or suspected of having a malignancy reactive with the antibody or fragment.

Radiotherapeutic immunoconjugates labeled with iodine-125

A method is set forth for treatment of hypoxic tumors by interstitial injection of oxygen bearing fluorocarbon emulsions directly into the hypoxic zone of the tumor followed by radiation treatment.

Interstitial administration of perfluorochemical emulsions for

Process of radioimaging the myocardium of mammals using intravenous injection of radiolabeled lipophilic cations of quaternary ammonium, quaternary phosphonium or quaternary arsonium compounds of the formula ##STR1## where R.sub.1 and R.sub.2 are alkyl or aryl groups, R.sub.3 and R.sub.4 are phenyl or benzyl groups, X is Br.sup.-, I.sup.- or Cl.sup.-, L is I.sup.123, I.sup.125, I.sup.131, Br.sup.77, Br.sup.82 or F.sup.18 and Z is nitrogen, phosphorous or arsenic.

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Downingtown, PA, United States of America

David V Woo