Avedro, Inc.

Identix Corporation

Other

Morphotrust Usa, LLC

Retica Systems, Inc.

David Usher

Marc David Friedman

David Muller

Yasunari Tosa

Desmond Christopher Adler

Mikhail Smirnov

Nicholas A Accomando

Tim McNerney

Pablo Casaverde

Vladimir Ruzhitsky

Faisal Bashir

Grace Elizabeth Lytle

John Marshall

David C Iannetta

Jun Zhang

Don Yansen

David J Hitchcock

Pavel Kamaev

Robert L Kuykendal

Ronald Scharf

Evan Sherr

Radha Pertaub

Stephen F Daly

Romina Marie Johnson Jose

Greg Heacock

Amit Mukherjee

Behrouz Tavakol

Jason J Hill

Gregory Lee Heacock

Ronald S Deichmann

Satish Herekar

Ronald S Delchmann

Gregory L Heacock

Alex Yildizyan

Nichoas A Accomando

William Eddington

Jie Zhang

Kikhail Z Smirnov

An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.

Systems and methods for generating patient-specific corneal cross-linking treatment patterns

An example system for tracking motion of an eye during an eye treatment includes an image capture device configured to capture a plurality of images of an eye. The system includes controller(s) including processor(s) that receive the plurality of images from the image capture device. The processor(s) implement a plurality of trackers. Each tracker is configured to detect a respective feature in the plurality of images and provide, based on the respective feature, a respective set of data relating to motion of the eye. The respective features detected by the plurality of trackers are orthogonal relative to each other and the respective sets of data provided by the plurality of trackers are independent of each other. The processor(s) coalesce the sets of data from the plurality of trackers and determine an indicator of the motion of the eye based on the coalesced sets of data.

Systems and methods for eye tracking during eye treatment

A corneal cross-linking system includes a light source configured to emit a photoactivating light. The system includes a spatial light modulator configured to receive the photoactivating light from the light source and provide a pixelated illumination. The spatial light modulator defines a maximum area for the pixelated illumination. The system includes a controller configured to cause the spatial light modulator to project a first pixelated illumination onto the cornea to photoactivate a cross-linking agent applied to a treatment area. The first pixelated illumination has an area that is smaller than the maximum area defined by the spatial light modulator. The controller is configured to determine movement of the cornea. In response to the movement, the controller controls the spatial light modulator to project a second pixelated illumination to the treatment area based on a translation and/or transformation of the first pixelated illumination to continue photoactivating the cross-linking agent.

A system for treating an eye includes a light source configured to provide photoactivating light that photoactivates a cross-linking agent applied to a cornea. The system includes one or more optical elements configured to receive the photoactivating light and produce a beam that defines a spot of the photoactivating light. The system includes a scanning system configured to receive the beam of the photoactivating light and to scan the spot of the photoactivating light along a first axis and a second axis to form a scan pattern on the cornea to generate cross-linking activity.

Photoactivation systems and methods for corneal cross-linking treatments

In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.

Systems and methods for determining cross-linking distribution in a cornea and/or structural characteristics of a cornea

Systems and methods employ bioresorbable corneal implants to treat corneal ectatic disorders and/or refractive errors. The corneal implants may be formed from a porous microstructure that can encourage the proliferation of endogenous keratocytes. As such, the corneal implants act as tissue scaffolds that promote tissue growth to increase the biomechanical stability and/or change the shape of the cornea. Over time, the corneal implants may resorb via hydrolysis or enzymatic breakdown, negating the risks of inflammation, scarring, or foreign body response. The corneal implants may also employ drug coating(s) to promote tissue growth.

Bioresorbable corneal implants

A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.

Systems and methods for monitoring time based photo active agent delivery or photo active marker presence

A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.

Multimodal ocular biometric system

A method and apparatus for operating on skimmed oil/water picked up from a body of water to separate the oil from the water and discharge the oil-free water back into the body of water, first feeds the skimmed oil/water into a gravity settling tank wherein the oil tends to settle above the water, removing relatively oil-free water from the bottom of the tank and measuring its oil content with an oil concentration sensor, and either returning the oil/water flow to the settling tank for further processing if the measured concentration of oil exceeds predetermined limits or discharging the water back into the body of water if the oil concentration is measured to be less than the predetermined value.

Oil decanting system

Biometric systems capture and combine biometric information from more than one modality, employing digital processing algorithms to process and evaluate captured images having data for a biometric characteristic. Such digital algorithms may include a pupil segmentation algorithm for determining a pupil image in the captured image, an iris segmentation algorithm for determining an iris image in the captured image, an eyelid/eyelash segmentation algorithm for determining an eyelid/eyelash image in the captured image, and an algorithm for measuring the focus on the iris. Some embodiments employ an auto-capture process which employs such algorithms, in part; to evaluate captured images and obtain the best possible images for biometric identification.

Multimodal ocular biometric system and methods

A system for multimodal biometric identification has a first imaging system that detects one or more subjects in a first field of view, including a targeted subject having a first biometric characteristic and a second biometric characteristic; a second imaging system that captures a first image of the first biometric characteristic according to first photons, where the first biometric characteristic is positioned in a second field of view smaller than the first field of view, and the first image includes first data for biometric identification; a third imaging system that captures a second image of the second biometric characteristic according to second photons, where the second biometric characteristic is positioned in a third field of view which is smaller than the first and second fields of view, and the second image includes second data for biometric identification. At least one active illumination source emits the second photons.

Long distance multimodal biometric system and method

Growing community of inventors

Waltham, MA, United States of America

David Usher