Bend Research, Inc.

Dow Global Technolgoies LLC

Capsugel Belgium Nv

Bend Reserch, Inc.

David Thomas Vodak

Dwayne Thomas Friesen

Warren Kenyon Miller

David Keith Lyon

Daniel Elmont Dobry

Corey Bloom

Daniel Tod Smithey

Michael Mark Morgen

William Brett Caldwell

Hassan Benameur

Jonathan Leonard Cape

Maryline Clauzel

Disclosed are processes for forming compositions comprising small domains of an active agent and a matrix material, and methods of using them. A suspension of an active agent, a matrix material, a first solvent, and a second solvent is formed at a temperature T, heated to a temperature Tand spray dried.

Process for forming active domains dispersed in a matrix

The present disclosure relates to compositions of an aqueous colloidal dispersion of hydroxypropyl methyl cellulose acetate succinate (HPMCAS), and methods for making such colloidal dispersions.

Colloidal dispersion comprising HPMCAS

Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.

Pharmaceutical compositions of dextran polymer derivatives

Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent.

Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution

Pharmaceutical compositions are provided comprising (a) nanoparticles of an active agent and a dextran polymer derivative, and (b) a carrier material.

Pharmaceutical compositions of dextran polymer derivatives and a carrier material

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Bend, OR, United States of America

David Thomas Vodak