Living Proof, Inc.

University of California

Forge Therapeutics, Inc.

Blacksmith Medicines, Inc.

David Thomas Puerta

Daniel Griffith Anderson

Ronald P McLaughlin

Susan Alice Williams

Mitchell John DeRosa

Bryan Scott Akcasu

Richard Matthew Ramirez

Lorna Nagamoottoo-Casse

Amir Nashat

Min Teng

Baskar Nammalwar

Seth M Cohen

Jana Lewis

Jana A Lewis

Konstantin Taganov

Susan Alice Thiell

Kevin Thomas Love

Xiaoming Li

Holly Atton

Serge Convers-Reignier

Ian Yule

Alastair Parkes

Christian Perez

Michelle Southey

Adele Faulkner

Ronald P Mclaughlin

Cy V Credille

Mitchell John Derosa

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

Antibacterial compounds

Provided herein is an LpxC inhibitor compound, as well as methods of making and pharmaceutical compositions comprising said compound, and methods of use thereof in the treatment of disease that would benefit from treatment with an LpxC inhibitor, including gram-negative bacterial infections such as urinary tract infections and the like.

LpxC inhibitor and methods of making

Provided herein are heterocyclic derivative compounds of Formula (II), and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like. 

There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease

The present teachings relate to hydroxypyrimidinone derivatives of Formula II, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections. 

Substituted pyrimidines for treating bacterial infections

The present teachings relate to pyrone derivatives, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections.

Pyrone based compounds for treating bacterial infections

The present teachings relate to hydroxypyrimidinone derivatives of Formula IV, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections. 

Substituted hydroxypyrimidinones for treating bacterial infections

The present invention provides compositions, kits and methods for treating scalp hair. The compositions include fluorinated (but not perfluorinated), non-polymeric compounds in a suitable excipient to provide beneficial effects on hair.

Hair care compositions and methods of treating hair

Dyes, compositions comprising dyes and methods for using the same are provided.

Coloring agents and methods of use thereof

The present invention provides kits and methods for treating hair on the scalp comprising non-toxic compositions providing beneficial effects on hair without employing high temperatures, free radical initiators or rinsing hair after applying the compositions.

Hair care compositions and methods of treating hair using same

Hair treatment compositions are disclosed comprising a &#x3b2;-amino ester compound in a cosmetically acceptable vehicle, such as a spray or cream. In embodiments, the compounds include a polybutadiene moiety. Methods of treating hair with the compositions to impart volume, texture and definition are also disclosed.

Beta-amino ester compounds and uses thereof

Compositions are disclosed comprising novel fluorinated cationic alcohols in a cosmetically acceptable vehicle. The fluorinated compounds alter a surface property of the hair to provide hair conditioning, for example. In embodiments, the compounds have improved water solubility and deposition properties.

Growing community of inventors

Melrose, MA, United States of America

David Thomas Puerta