Warner-Lambert Company

University of Michigan

David Thomas Dudley

Alexander James Bridges

Alan Robert Saltiel

Haile Tecle

Stephen Douglas Barrett

Annette Marian Doherty

Mel C Schroeder

Donna Reynolds Cody

John C Hodges

Michael D Taylor

Thomas A Pugsley

James Leslie Mobley

Stephen J Weiss

The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject, inhibiting angiogenesis, or treating a fibrotic disorder. The invention further provides a method of producing an antibody, the method comprising propagating cancer cells in a 3-dimensional matrix; immunizing a mammal with the propagated cancer cells; and isolating an antibody from the immunized mammal. A method of identifying an agent that inhibits cancer cell proliferation also is provided.

Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation

Phenylamino benzhydroxamic acid derivatives of the formula where R, R, R, R, R, and Rare hydrogen or substituent groups such as alkyl, and where Ris hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.

4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors

Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula

2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives

Phenylamino benzhydroxamic acid derivatives of formula (I) where R , R , R , R , R , and R are hydrogen or substituent groups such as alkyl, and where R is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.

4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors

This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of Formula I and II:

Treatment of asthma with MEK inhibitors

2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors

The present invention provides a method for treating or preventing septic shock. Specifically, the present invention provides a method of treating or preventing septic shock by administering to a patient a MEK inhibitor.

Method of treating or preventing septic shock by administering a MEK inhibitor

The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT.sub.2 receptors to treat memory loss.

Imidazo-pyridine angiotensin II antagonists used to treat memory loss

The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT.sub.2 receptors.

Growing community of inventors

Ann Arbor, MI, United States of America

David Thomas Dudley