Imaginab, Inc.

Nant Holdingsip, LLC

Nantomics, LLC

Nantbio, Inc.

David T Ho

Tove Olafsen

Christian P Behrenbruch

Giti Agahi

Jason Romero

Arye Lipman

Patrick Soon-Shiong

Kayvan R Niazi

Shahrooz Rabizadeh

Chunlin Tao

Oleksandr V Buzko

Justin Golovato

Paul Weingarten

Heather McFarlane

Anna B Juncker-Jensen

Niazi Kayvan

Anna Juncker-Jensen

Tove Olafson

Heather Mcfarlane

Antigen binding constructs that bind to CD8, for example antibodies, including antibody fragments (such as scFv, minibodies, and cys-diabodies) that bind to CD8, are described herein. Methods of use are described herein.

Antigen binding constructs to CD8

In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided.

J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use

Antigen binding constructs that bind to CD3, for example antibodies, including antibody fragments (such as minibodies and cys-diabodies) that bind to CD3, are described herein. Methods of use are described herein.

Antigen binding constructs to CD3

Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

Compositions and methods of targeting mutant K-RAS

J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use

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Long Beach, CA, United States of America

David T Ho