Smithkline Corporation

Smithkline Beckman Corporation

Smithkline Beecham Corporation

Other

David T Hill

Joseph Weinstock

Randall K Johnson

Ivan Lantos

Blaine M Sutton

John G Gleason

James Martin Samanen

Gerald R Girard

Paul E Bender

Judith Hempel

Bernard Loev

Christopher K Mirabelli

John Duncan Elliott

William Edward Bondinell

Charles E Berkoff

Barry M Weichman

William E Cass, Iii

Judith Hampel

Pamela L Cass

Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.

Substituted imidazolyl-alkyethio-aldanoic acids

Endothelin receptor antagonists

Substituted imidazolyl-alkylthio-alkanoic acids

Substituted histidines

Method of antagonizing angiotensin II receptors in mammals using

N-(heteroaryl) imidazolyl-alkenoic acids having angiotension II receptor

Substituted [1H-imidazol-5-ylialkanoic acids having angiotension II

Substituted histidines having angiotension II receptor antagonist

Substituted N-(imidazolyl)alkyl alanine derivatives

The invention disclosed is a picnic mat, multipurpose tote bag and securing means assembly suitable for use by a group of people for picnics and concerts etc. The picnic mat is provided with loops on the underside corners as well as corresponding ground securing devices or pins for holding said mat to the ground. Also provided is a pin manipulating tool to facilitate the insertion in and removal of said pins from the ground without damage to the picnic mat. This invention is also provided with a multipurpose tote bag with an inner pouch for containing said pins and a restraining strap for said manipulating tool.

Picnic mat and carrying bag assembly

2-pyridyl and 4-pyridyl phosphine gold compounds of the formula: ##STR1## and 2-pyridyl phosphine gold compounds of the formula: ##STR2## and pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound.

'2-pyridyl and 4-pyridyl phosphine gold (I) anti tumor complexes'

Compounds, pharmaceutical compositions and a method for treating tumors by administering an effective tumor cell growth-inhibiting amount of a .alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon compound or a [.alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon] digold(I), digold(III, disiliver(I) or dicopper(I) complex to an animal afflicted by such tumor cells.

Antitumor compounds

Novel compounds, pharmaceutical compositions and a method of inhibiting the 5-lipoxygenase products in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a 2,2'-[1,2-ethanediylbis-(thio)]-bis-1H-imidazole or 2,2'-[1,3-propan-2-onediylbis-(thio)]bis-1H-imidazole, or a pharmaceutically acceptable salt thereof, to such animal.

Inhibition of the 5-lipoxygenase pathway utilizing certain

The imidazolylthio substituted alkanoic acids represented by the formula (I) or (IA) as defined herein have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

Imidazolylthioalkenoic acids and -alkenols and leukotriene antagonistic

Antitumor pharmaceutical compositions and methods for treating tumors employing .alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon derivatives or [.alpha.,.omega.-bis(disubstituted phosphino)hydrocarbon] digold(I), digold(III), disilver(I), and dicopper(I) derivatives are disclosed.

Antitumor pharmaceutical compositions and methods for treating tumors

Growing community of inventors

North Wales, PA, United States of America

David T Hill