The University of Arizona

Other

Arizona Board of Regents, a Body Corporate

Core Blood Registry, Inc.

David T Harris

Evan M Hersh

Eugene W Gerner

Tom C Tsang

Mark L Witten

Brian L Pipes

Linda C Meade-Tollin

Xianghui He

Farha Vasanwala

Jesse O Kramer

Tom Tsang

Thomas Eldon Moore

Thomas Chun-Chang Tsang

Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell. Antibodies against ubiquitin are shown to inhibit tumor cell migration.

Stem cell fusion model of carcinogenesis

Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell (FIG.). Antibodies against ubiquitin are shown to inhibit tumor cell migration.

Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.

Hyperthermic inducible expression vectors for gene therapy and methods of use thereof

Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other genes of interest in mammalian cells are provided, as well as methods of using the same.

The present invention relates to inducible gene expression constructs and methods of inducing gene expression using a combination of inducing agents.

Inducible expression vectors and methods of use thereof

Substance P aerosols are effective in replenishing immune systems compromised by environmental toxicants. They are also useful for prophylaxis against and treatment of infections and neoplasms. They are useful for accelerating maturation of immune systems or maintaining immune function, as well. Chronic exposure to hydrocarbons is particularly damaging to the immune system, and thus this occupational hazard can be counteracted by treatment with substance P aerosols.

Substance P treatment for immunostimulation

A computer-based mixed-use cord stem cells registry system, method and device are provided for developing and maintaining a mixed-used bank of placental and umbilical cord stem cells and for the resultant bank. The cord stem cells, or a fraction thereof, is stored in a bank for the potential use of the donor and potentially the actual family of the donor child or from an unrelated person for whom the cord stem cells are a match. The system makes the cord stem cells available to the family until the blood sample is found to match a non-family member in need of the cord stem cells. At this time the family is given an option of keeping the sample for themselves or of providing it to the non-family member along with current information on the donor family.

Growing community of inventors

Tucson, AZ, United States of America

David T Harris