Triad National Security, LLC

Northern Arizona University

University of California

Dixie State University

The College of New Jersey

Arizona Board of Regents, a Body Corporate

David T Fox

Andrew Koppisch

Rico Del Sesto

Samir M Mitragotri

Michael Zakrewsky

Joseph Baker

Katherine Lovejoy

Alexanndra J Heyert

Gerrick E Lindberg

Joshua R Greene

Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.

Antibiofilm formulations

The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.

Ionic liquids for transdermal drug delivery

Growing community of inventors

Los Alamos, NM, United States of America

David T Fox