Cree Gmbh

Know Bio, LLC

Cree Huizhou Solid State Lighting Company Limited

Creeled, Inc.

Cree Hong Kong Limited

Cree Huizhou Opto Limited

David T Emerson

Michael John Bergmann

Christopher P Hussell

Kevin Haberern

John Adam Edmond

Peter Scott Andrews

Raymond Rosado

James Ibbetson

Brian Thomas Collins

Amber Christine Abare

Nathan Stasko

Jeffrey Carl Britt

Adam Cockrell

F Neal Hunter

Rebecca McDonald

Bernd P Keller

Thomas Matthew Womble

Matthew Donofrio

Jesse Colin Reiherzer

Amber Christine Salter

Antony Paul Van De Ven

Hua-shuang Kong

Joseph Gates Clark

Kathleen Marie Doverspike

Ashay Chitnis

Michael P Laughner

Chi Keung Chan

James Michael Lay

Ronan P Le Toquin

Gerald H Negley

Nicholas William Medendorp, Jr

Eric J Tarsa

David Beardsley Slater, Jr

Van Mieczkowski

Michael O'Loughlin

Katelyn P Reighard

Chak Hau Pang

Yue Kwong Victor Lau

Fei Hong Li

Michael John Bergman

Howard Dean Nordby, Jr

Hua-Shuang Kong

Florin A Tudorica

Daniel Carleton Driscoll

Jeremy S Nevins

Chi Keung Alex Chan

Yue Kwong Lau

Jacob Kocher

Theodore D Lowes

Thomas Goldthwaite Coleman

Jasper S Cabalu

Jayesh Bharathan

Ting Li

Xuan Wang

Harry A Seibel

Mark Raffetto

Xiang Fei

Alex Chi Keung Chan

Chak Hau Charles Pang

Zhenyu Zhong

Michael Allen Pennington

Hao Liu

Robert Allen Garner

Keenan Carlyle Brown

Zhi Kuan Zhang

Ju Zuo Sheng

Jun Zhang

Arpan Chakraborty

Colin Kelly Blakely

Sung Chul Joo

Erin R F Welch

Derek Miller

Mark McClear

Arthur Fong-Yuen Pun

Yankun Fu

Winston T Parker

Hua Shuang Kong

Harsh Sundani

Wooh Jae Kim

Justin Lydon

Luis Breva

James Seruto

Mark McOlear

Kevin W Haberen

Van Mieczowski

Nikolas Hall

Jim Wood

Daniel Cronin

Anoop Mathew

Fabian Rol

David Dean Seibel

Jason Hansen

Howard Nordby

Kevin W Haberern

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity. Illumination devices may be configured to communicate with networks and/or servers to provide control and/or management of phototherapy treatments.

Illumination devices for inducing biological effects

Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.

Phototherapeutic light for treatment of pathogens

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.

Devices and methods for impinging light on tissue to induce one or more biological effects, and more particularly enhanced testing and characterization techniques for phototherapeutic light treatments are disclosed. Such testing and characterization techniques may be particularly useful in the evaluation and development of light-based treatments for various infectious diseases, including multiple variants of SARS-CoV-2. In particular aspects, testing and characterization techniques are related to the direct testing of differentiated tissue models of human airway epithelia that have been exposed to various pathogens. Phototherapeutic light treatments and corresponding treatment protocols for light are also described that not only inactivate SARS-COV-2 variants in cell-free suspensions, but also inhibit SARS-CoV-2 infections at multiple stages of infection in tissue models of human airway epithelia in a variant-agnostic manner.

Enhanced testing and characterization techniques for phototherapeutic light treatments

An LED wafer includes LED dies on an LED substrate. The LED wafer and a carrier wafer are joined. The LED wafer that is joined to the carrier wafer is shaped. Wavelength conversion material is applied to the LED wafer that is shaped. Singulation is performed to provide LED dies that are joined to a carrier die. The singulated devices may be mounted in an LED fixture to provide high light output per unit area.

Wafer level packaging of light emitting diodes (LEDs)

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity. Particular illumination devices are disclosed that provide safe and effective treatments for upper respiratory tract infections, including coronaviridae and orthomyxoviridae.

A method is disclosed for forming a blended phosphor composition. The method includes the steps of firing precursor compositions that include europium and nitrides of at least calcium, strontium and aluminum, in a refractory metal crucible and in the presence of a gas that precludes the formation of nitride compositions between the nitride starting materials and the refractory metal that forms the crucible. The resulting compositions can include phosphors that convert frequencies in the blue portion of the visible spectrum into frequencies in the red portion of the visible spectrum.

Phosphor composition

Oral illumination device

Growing community of inventors

Chapel Hill, NC, United States of America

David T Emerson