University of Michigan

David T Burke

Mark A Burns

Carlos H Mastrangelo

Brian N Johnson

James R Webster

Bradley Foerster

Darren Jones

Timothy S Sammarco

Francis P Man

Yakeitha Fields

Adam Kaiser

Wayne F Beyer

John D DeNuzzio

Ponnambalam Selvaganapathy

The present invention relates to microfabrication and utilization of microscale electrophoresis devices as well as the separation and detection of biomolecules in microscale electrophoresis devices. The device of the present invention utilizes novel fabrication and detection methods.

Microscale electrophoresis devices for biomolecule separation and detection

The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

Microscale reaction devices

Disclosed are methods and compositions for isothermal amplification of nucleic acids in a microfabricated substrate. Methods and compositions for the analysis of isothermally amplified nucleic acids in a microfabricated substrate are disclosed as well. The microfabricated substrates and isothermal amplification and detection methods provided are envisioned for use in various diagnostic methods, particularly those connected with diseases characterized by altered gene sequences or gene expression.

Chip-based isothermal amplification devices and methods

Microscale devices and reactions in microscale devices

Growing community of inventors

Ann Arbor, MI, United States of America

David T Burke