Oriel Therapeutics, Inc.

Smith + Nephew

Dyson Technology Limited

Sun Pharma Advanced Research Company Limited

Cambridge Consultants Limited

Ds-technology Gmbh

David Stuart Harris

Scott Alexander Lewis

Andrew Murray Gow

Thomas W Ruckdeschel

Jonathan David Tuckwell

Simon James Smith

Edward William Vernon-Harcourt

Nathan Wrench

Benjamin Gordon

Jake Turner

Edward Yerbury Hartwell

James Grant Skakoon

David A Schuelke

Stephen Jacob

Charles A Buckner, Iii

Gerald A Thoe

Rachel Striebig

George McGee Perkins

Matthew Allen

Lee Wood

Subhas Balaram Bhowmick

Prashant Kane

Abhijit Takale

Ricardo Gomiciaga-Pereda

John Kenneth Hainsworth

Philip David Canner

Gordon James Howes

Satish Madhukar Gokhale

Richard Francis Day

Jonathan Guillaume Jamin

Jonathan Wilkins

Duncan Aleck Bishop

Andrew Gow

Greg Beard

Ganesh Sangaiah

Ajay Nandgaonkar

Samantha Anne Musgrave

Becky Lynn Pilditch

Matthew David Allen

Anthony Joseph Dummelow

Benjamin Evans

Jamie Alan Greenwood

Jonathan Hugh Wilkins

Scott Lewis

Jon Tuckwell

Charles A Buckner

A Charles Buckner Iii

LEWIS;Scott Alexander

Methods and apparatuses for detecting full waste canister and/or fluid flow path blockage conditions are disclosed. Also disclosed are methods and apparatuses for controlling a pump. In some embodiments, flow of fluid can be restricted in a portion of the fluid flow path. A controller can be configured to compare a difference in pressure values upstream and downstream of a fluid flow restrictor to a pressure difference threshold, and determine based on the comparison whether to activate an alarm indicating the full waste canister condition or the fluid flow path blockage condition. The controller can be additionally or alternatively configured to determine a fluid flow using a flow meter, open a selectable valve in response to a comparison of the fluid flow with a fluid flow threshold, determine fluid flow after opening the valve, and determine based on the fluid flow after opening the valve whether to activate the alarm.

Systems and methods for controlling operation of negative pressure wound therapy apparatus

An apparatus for aerosolized powder delivery includes first and second chambers containing gas at first and second pressures, respectively, above atmospheric pressure. A powder is contained within the first or second chamber. The first chamber has a first external wall and a separating wall shared with the second chamber. The first external wall or the separating wall is configured to rupture if the pressure difference across it becomes equal to or greater than a threshold pressure difference. Specifically, the apparatus is configured so that the difference between the second pressure and atmospheric pressure is greater than the threshold pressure difference. Initially, the difference between the second and first pressures is less than the pressure difference required to rupture the separating wall, and the difference between the first pressure and atmospheric pressure is less than the pressure difference required to rupture the first external wall.

Apparatus and method for providing aerosolized powder delivery

A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Dry powder inhalers with dual piercing members and methods of operating same

Dry powder inhalers and methods are provided that facilitate deagglomeration of powdered medicament during inspiration. A dry powder inhaler includes a dry powder medicament container assembly, and an elongated dry powder delivery tube having an inlet at one end that communicates with a dose container, and an outlet or inhalation port that extends from the inhaler housing at an opposite end. The delivery tube includes one or more apertures adjacent the inlet that cause cyclonic or turbulent airflow through the delivery tube. The inner surface of the delivery tube has a polygonal configuration and the cyclonic air stream bounces off the polygonal inner surface numerous times as the air stream flows through the delivery tube. Another dry powder inhaler includes a deagglomeration chamber with a polygonal inner surface. An air stream containing dry powder medicament is directed into the deagglomeration chamber and impacts the polygonal inner surface numerous times.

Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods

Dry powder inhalers are described with an inhaler body defining an enclosed cavity space and at least one of (a) an endless strip having opposing primary surfaces, the strip comprising a plurality of spaced apart blisters or dose containers holding dry powder medicament. The inhaler also has an inhalation exit flow path in the inhaler body in communication with at least one blister or at least one dose container held by the strip in a dispensing position and a piercer configured to release dry powder medicament from the blister or dose container in the dispensing position.

Dry powder inhalers with endless strips and cooperating piercers and related methods

Dry powder inhalers with dual piercing members

A method and apparatus for alerting a user of topical negative pressure therapy apparatus to a full waste canister condition are described, the apparatus comprising a device having vacuum pump means and a waste canister connected to the device and the waste canister operably connected to a wound dressing by aspiration conduit means for aspirating fluid from the wound, the aspiration conduit means, the waste canister and the device providing a fluid flow path therethrough and the vacuum pump means providing fluid flow through the apparatus, the apparatus further comprising fluid flow restriction means in the fluid flow path of said vacuum pump and fluid pressure sensing means upstream and downstream of said fluid flow restriction means.

Apparatus and method for applying topical negative pressure

Inhalers with an inhaler housing having a dose container disk having inner and outer perimeters mounted in the housing. The dose container disk has a plurality of circumferentially spaced apart dose containers with dry powder therein. The inhalers also include a piercer carriage with a piercer mounted in the inhaler. The piercer carriage is in communication with a resilient member that radially biases the piercer carriage to radially travel to align the piercer with an underlying or overlying dose container.

Inhaler mechanisms with radially biased piercers and related methods

A dry powder inhaler comprises two parts () connected by an integrally molded, e.g. living hinge (), so as to be moveable from an open position to a closed position. At least one of the parts () defines at least part of a circulating airflow chamber (), wherein when said parts () are in said closed position, the inhaler comprises an airflow path including the circulating airflow chamber ().

Hinged dry powder inhaler comprising a circulating airflow chamber

Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Inhalers with airway disks having discrete airway channels and related disks and methods

Dry powder inhalers with rotatable piercing mechanisms facilitate the use of dose container assemblies having dose containers arranged in concentric rows. A piercing mechanism is operably associated with the dose container assembly and is configured to pierce sealants that seal a dose container. The piercing mechanism is rotatable such that it can serially alternate between the two rows of dose containers. The piercing mechanism includes a rotatable drum, an elongate piercing member, and a biasing member operably associated with the piercing member. The rotatable drum has an open end, an opposite closed end, and a cylindrical wall that extends from the closed end and terminates at the open end. The closed end includes an aperture formed therein in a location adjacent to the wall. The elongate piercing member is extended and retracted through the aperture to pierce the sealants of a dose container.

Dry powder inhalers with rotating piercing mechanisms and related devices and methods

The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.

Inhalation device

Growing community of inventors

Milton, United Kingdom

David Stuart Harris