Astrazeneca Ab

David Stephen Clarke

Roger John Butlin

Thorsten Nowak

Jeremy Nicholas Burrows

Michael Howard Block

Janet Elizabeth Pease

Paul Ro Whittamore

Amides as inhibitors for pyruvate dehydrogenase

Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally oxidised to form the N-oxide; R and R are substituents as defined within; R and R are defined within and are alkyl or halo alkyl or together form a halocycloalkyl ring; R is a substituent as defined within; Y&mdash;Z is a linking group as defined within; are useful in the production of a elevation of PDH activity in a warm-blooded animal such as a human being. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are described.

Benzenesulfonamide-derivatives and their use as medicaments

Growing community of inventors

Macclesfield, United Kingdom

David Stephen Clarke