Gilead Sciences, Inc.

Yeda Research and Develpment & Co. Ltd

Orsobio, Inc.

The Liver Company Inc.

David Sperandio

Hai Yang

Michael Sangi

Jay P Parrish

Dustin S Siegel

Hon Chung Hui

Richard L Mackman

Britton Kenneth Corkey

Oliver L Saunders

Constantine G Boojamra

Kerim Babaoglu

Robert H Jiang

Michael R Mish

Gregory F Chin

Kristyna M Elbel

Eugene J Eisenberg

Jeff A Zablocki

Jinfa Du

Tetsuya Kobayashi

Samuel E Metobo

Ruben Martinez

Evangelos Aktoudianakis

Sophie Shevick

Gregory Notte

Rick Andrew Lee

Joshua A Kaplan

Julie Farand

Manuel Munoz

Casey Lockwood Olen

Lianhong Xu

James Ming Chen

Dmitry Koltun

Petr Jansa

Eric Q Parkhill

Suet Chung Yeung

Ryan McFadden

Julian Andrew Codelli

Mark J Bartlett

Joshua J Van Veldhuizen

Yunfeng Eric Hu

Alan X Huang

Xiaochun Han

Jennifer Alissa Loyer-Drew

Jennifer Leigh Cosman

Jason K Perry

Rotem Sorek

Michael O' Neil Hanrahan Clarke

Arthur Machlenkin

Tim Hansen

Lianet Noda Garcia

Helena Shomar Monges

Disclosed herein are 3,4-didehydro- and 3'-deoxy-3,4-didehydro-compounds and pharmaceutical compositions thereof. Methods of use of these pharmaceutical compositions include those for treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SAR-CoV-2, EBV, BKV, JCV and HCMV.

Anti-viral and anti-tumoral compounds

Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives

The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

Imidazopyrimidine derivatives

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Compounds and methods for antiviral treatment

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R, R, R, R, R, R, R, and Rare described herein.

Benzimidazole derivatives as bromodomain inhibitors

The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Pyrazolo[1,5-A]pyrimidines for antiviral treatment

The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors of Formula I: or pharmaceutically acceptable salts thereof, in which X, L, n, m, R, R, R, R, R, and Rare as defined herein, as well as pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using the same to treat conditions mediated by IDO1.

Benzimidazole and imadazopyridine carboximidamide compounds

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R, R, R, R, R, and X are described herein.

Benzimidazolone derivatives as bromodomain inhibitors

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula I wherein R, R, R, R, R, W, X, and Z are as described herein.

Quinoline derivatives as bromodomain inhibitors

The present invention relates to anti-RSV compounds of Formula (I) and methods for use of the compounds in the treatment and prevention of RSV infection. 

Anti-RSV compounds

Growing community of inventors

Palo Alto, CA, United States of America

David Sperandio