Beckman Coulter, Inc.

David Sorrentino

Richard Wolf

Takayuki Mizutani

Glenn A Davis

Creigh Thompson

Brian Kozicki

Laura Holmes

Assays () may be performed with a luminometer () having a chassis () that may include a reaction vessel chamber (). The luminometer () may also include a light passage () that intersects the reaction vessel chamber (). The luminometer () may also include a cap () that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber () and from entering the light passage (). The cap () may provide access to the reaction vessel chamber () when in an open configuration. The luminometer () may also include a calibration light source () optically coupled to one end of the light passage () and a light detector () optically coupled to another end of the light passage (). The light detector () may include a sensing element for receiving light from the light passage ().

System for analog light measuring and photon counting in chemiluminescence measurements

A luminometer () includes a light detector () configured to sense photons (). The luminometer () includes an analog circuit () configured to provide an analog signal () based on the photons () emitted from assay reactions over a time period and a counter circuit () configured to provide a photon count () based on the photons () emitted from the assay reactions over the time period. The luminometer () includes a luminometer controller () configured to, in response to an analog signal value of the analog signal () being greater than a predetermined value, determine and report a measurement value of the photons () emitted from the assay reactions over the time period based on the analog signal value of the analog signal () and a linear function (). Optionally, the linear function () is derived from a relationship between the analog signal () and the photon count ().

Analog light measuring and photon counting in chemiluminescence measurements comprising a luminometer controller to compare digitized photon count to a discreet-analog crossover value

Analog light measuring and photon counting with a luminometer system for assay reactions in chemiluminescence measurements

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Chaska, MN, United States of America

David Sorrentino