University of Massachusetts

Ipratech Sa

Apicells Inc.

David Sergeant

Thierry Poskin

Geoffrey Esteban

Olivier Berteau

Jérémie Cubeta

Seongkyu Yoon

An analysis system features a confinement device, an optical measurement device, a flow device, a collecting conduit, and an actuation device. The confinement device comprises a measurement chamber, optically transparent first and second measurement surfaces that face each other across a distance that defines a thickness of the measurement chamber, and a flexible membrane that forms a seal with the measurement surfaces to laterally delimit the measurement chamber. When the collecting is sealed with a container, a connection is established that permits a liquid sample to be collected from the container. The optical measurement device emits light towards the chamber and detects light that has been transmitted through it, wherein the flow device causes liquid to flow through the collecting conduit between the container and the measurement chamber. The actuation device varies the thickness.

Analysis system including a confinement device with variable-size measurement chamber partially delimited by a flexible membrane

Embodiments provide a distributed bioreactor system in which a plurality of modular bioreactors are operated in parallel to produce and maintain a biological cell culture. A central or nurse perfusion bioreactor produces and maintains a cell culture and transfers portions of the cell culture to a plurality of modular peripheral perfusion bioreactors, each of which produces and maintains the cell culture in turn. In order to prevent contamination and facilitate segregation of particular peripheral bioreactors, the distributed system is configured such that one-way fluid communication is established from the central/nurse bioreactor to each of the peripheral bioreactors while maintaining fluid isolation among the peripheral bioreactors. Each modular peripheral bioreactor unit has a plug-and-play configuration and may be plugged into or otherwise coupled to the central/nurse bioreactor to scale up the overall size of the cell culture without requiring sterilization or redesign or reconfiguration of the system.

Distributed perfusion bioreactor system for continuous culture of biological cells

Growing community of inventors

Ecaussines, Belgium

David Sergeant