Gigagen, Inc.

Gigamune, Inc.

Natera, Inc.

David Scott Johnson

Adam Shultz Adler

Rena Aviva Mizrahi

Matthew James Spindler

Everett Hurteau Meyer

Yoong Wearn Lim

Michael Asensio

Kacy Stadtmiller

Sheila Keating

Angelica V Medina-Cucurella

Ariel Niedecken

Emily Benzie

Matthew Rabinowitz

Zachary Demko

Milena Banjevic

Dusan Kijacic

Dimitri Petrov

Jing Xu

Ellen Wagner

Erica Lyn Stone

Robert Edgar

Taylor Weller

Josh Sweetkind-Singer

Ayla Lynn Nelson

Zachary Paul Demko

Provided herein are antigen-binding proteins (ABPs) that selectively bind to CTLA-4 and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.

Anti-CTLA-4 binding proteins and methods of use thereof

Provided herein are compositions comprising recombinant polyclonal proteins (RPPs) derived from mammalian plasma cells and plasmablasts. Also provided are methods of using the RPPs.

Recombinant polyclonal proteins targeting COVID-19 and methods of use thereof

The present disclosure relates to a novel, engineered enveloped vector that can be used for gene delivery. The engineered enveloped vector comprises an engineered envelope comprising: (a) a viral envelope protein and optionally, (b) a non-viral membrane-bound protein. The present disclosure also provides a method of making and using the engineered enveloped vector.

Engineered enveloped vectors and methods of use thereof

Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.

Recombinant fusion proteins and libraries from immune cell repertoires

Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

Systems and methods for massively parallel combinatorial analysis of single cells

Provided herein are compositions comprising recombinant polyclonal protein (RPP) derived from mammalian plasma cells and plasmablasts. Specifically, RPPs specific to Zika virus are provided. Also provided are the methods of using the RPP for treatment of viral infection and the methods of making the RPPs.

Recombinant polyclonal proteins targeting Zika and methods of use thereof

Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.

System and methods for massively parallel analysis of nucleic acids in single cells

Provided herein are compositions comprising recombinant mammalian cells that express recombinant T cell rectors with specificity against EBV or CMV peptide:MHC antigens. Also provided are therapeutic methods of using the recombinant mammalian cells as cell therapies against viral infections.

Engineered cells expressing anti-viral T cell receptors and methods of use thereof

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San Francisco, CA, United States of America

David Scott Johnson