University of Kentucky Research Foundation

David S Watt

Chunming Liu

Vitaliy M Sviripa

Wen Zhang

Joe Chappell

Sylvie Garneau-Tsodikova

Shigeru Okada

Vivek M Rangnekar

Timothy P Devarenne

Mykhaylo S Frasinyuk

Svitlana P Bondarenko

Ravshan Burikhanov

Thomas D Niehaus

Peter Anthony Crooks

Stefan Kwiatkowski

Linda P Dwoskin

Jon Scott Thorson

Guangrong Zheng

Jared T Hammill

Markos Leggas

Nishad Thamban Chandrika

Mark Leggas

Na-Ra Lee

Derong Ding

Kip Guy

The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.

Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse

An antifungal composition and a method of treating a systemic fungal infection are provided herein. The antifungal composition includes a diaryl bishydrazone. The method includes administering a therapeutically effective amount of the diaryl bishydrazone to a subject in need thereof.

Antifungal compounds and methods of forming the same

A method of treating cancer in an individual includes a step of administering to the individual a pharmaceutically effective amount of (a) a first active agent adapted for producing secretion of prostate apoptosis response-4 (Par-4) from normal cells and (b) a second active agent adapted for elevating GRP78 receptors for Par-4 on a surface of a cancer cell in the individual.

Drugs for GRP78 cell surface translocation and Par-4 secretion

Halogenated phenylethynyl-substituted heterocycles that possess either an N-alkylamino or N,N-dialkylamino group attached to the heterocycle or halogenated phenylethynyl-substituted benzenes that a nitrogen-containing heterocycle attached to the benzene inhibit the proliferation cancer cells and are useful antineoplastic agents.

Phenylethynyl-substituted benzenes and heterocycles for the treatment of cancer

Cytisine-linked isoflavonoids, or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof, are useful for the treatment of conditions in which cells have a reliance on peroxisomal HSD17B4 to degrade very long chain fatty acids and provide necessary energy for cell proliferation, such as is seen in colorectal cancer and prostate cancer, for example.

Cytisine-linked isoflavonoid antineoplastic agents for the treatment of cancer

Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.

Bishydrazone-based antifungal agents

Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LS174T colon cancer cells through the inhibition of c-myc and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)). Such compounds are useful as antineoplastic agents.

Halogenated diarylacetylenes and methods of treating cancer

The subject technology relates to arylquinoline compounds and their use for treating cancer or cancer metastasis. The compounds of the subject technology promote cells to secrete a pro-apoptotic tumor suppressor, i.e., prostate apoptosis response-4 (Par-4), which in turn promote apoptosis in cancer cells or metastatic cells.

Arylquinoline and analog compounds and use thereof to treat cancer

Isoflavonoids or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof for the treatment of prostate cancer or for the treatment or inhibition of prostate cancer metastasis in a patient in need thereof are disclosed.

3-aryl-4H-chromene-4-ones as antineoplastic agents for the treatment of cancer

A method and system are provided for the production of triterpene including methylated triterpenes. The method and system include isolated nucleic acid sequences encoding triterpene methyltransferases such as triterpene methyltransferases 1, 2, 3. Advantageously, the method and system includes transgenic plant cells via an expression vector for triterpene methyltransferase and optionally various triterpene synthase and prenyltransferase all with tags directing these enzymes to the chloroplast of the transgenic plant cells for using the chloroplast methyl erythritol phosphate (MEP) pathway in the triterpene biogenesis.

Method and system for producing triterpenes

Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.

Stilbene analogs and methods of treating cancer

This application relates to the polypeptides, nucleic acid molecules, vectors, transfected cells, and methods for synthesis of triterpenes, including botryococcene.

Polypeptides, nucleic acid molecules, and methods for synthesis of triterpenes

Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. Such stilbene analogs include, for example, compounds of the following formula: wherein R, R, R, R, R, Rand Rare all H; Rand Rare independently H, halo, amino, alkylamino, dialkylamino, N-oxides of dialkylamino, arylalkylamino, trialkylammonium, mercapto, alkylthio, alkanoyl, nitro, nitrosyl, cyano, alkoxy, alkenyloxy, aryl, heteroaryl, sulfonyl, sulfonamide, CONRR, NRCO(R), NRCOO(R) or NRCONRR; R, Rand R, are independently, H, alkyl, aryl, heteroaryl or a fluorine; Ris NRRZ wherein Ris H, alkyl, alkoxy, aryl or heteroaryl, Ris an alkyl group, Z is a an unshared pair of electrons, H, alkyl or oxygen; and Rand Rare halogen.

Growing community of inventors

Lexington, KY, United States of America

David S Watt