Duke University

Biomimetix Jv, LLC

David S Warner

James D Crapo

Ines Batinic-Haberle

Ru-Rong Ji

Kimberly C Stone

Tong Liu

Mihai V Podgoreanu

Mark F Newman

Zhiquan Zhang

Qing Ma

Wulf Paschen

Wei Yang

Huaxin Sheng

A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.

Methods of treating pruritus

The present invention provides a method of treating, ameliorating or inhibiting sirtuin-associated disorders and/or conditions in a subject in need thereof, by administering to the subject an effective amount of an ANXA1 peptide.

Methods and compositions for activation of sirtuins with Annexin A1 peptides

Disclosed herein are methods relating to inhibiting or reducing proliferation of a cancer cell, for treating cancer in a subject in need of treatment, predicting the risk of progression of cancer to a more aggressive cancer, and screening for cancer in a subject, that comprise detecting and/or decreasing the levels of SUMO conjugated proteins and detecting and/or interfering with SUMO conjugation.

SUMO as a marker of cancer development and target for cancer therapy

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Chapel Hill, NC, United States of America

David S Warner