Nano-tex, Inc.

Zms, Llc.

Soane Technologies, Inc.

Aclara Biosciences, Inc.

Innovative Construction and Building Materials

2c Optics, Inc.

Soane Biosciences, Inc.

Rasor Associates, Inc.

Other

Alnis Biosciences, Inc.

University of California

Corning Precision Lens, Inc.

Soane Family Trust

Cosmetica, Inc.

Monogram Biosciences, Inc.

David S Soane

Michael R Houston

David A Offord

Zoya M Soane

Toshiaki Hino

Matthew R Linford

William Ware, Jr

Christopher D Tagge

Dan B Millward

Jacob Freas Pollock

Young C Bae

Theodore L Parker

Herbert H Hooper

Lennard F Torres

Stephen E Barry

Fredric J Lim

William L Sturm

Henry F Rugge

Donald R Ingenito

Ryan Lau

Eric G Green

Thomas B Ottoboni

Ken Saito

Lael Erskine

Matthew L Linford

Travis David Boone

Torleif Ove Bjornson

Thai Minh Nguyen

Randy M McCormick

Alexander P Sassi

Daniel J Suich

Anthony Lam

M Goretty Amigo

Michael G Perrott

Nam Thanh Le

Young Jae Bae

Rachel Decor

Stephen Pacetti

Andrew Goodwin

Charles Crocker

Kwan Chan

M Goretty Alonso Amigo

The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action. This invention further relates to processes for the preparation of such oligomers and polymers, and to compositions containing them. In some instances, surfactants, which can include an oligomer, polymer, small molecule, or other material, can be used to form a micelle for encapsulating the drug. The miscelle can be used to protect the drug until the drug is to be released.

Use of oligomers and polymers for drug solubilization, stabilization, and delivery

This invention is directed to fabric finishes or treatment preparations for nylon, polyester, and other textile and fibrous substrate materials that will render them hydrophilic. The finishes of the invention are comprised primarily of polymers that contain carboxyl groups, salts of carboxyl groups, or moieties that can be converted to carboxyl groups by some chemical reaction.

Hydrophilic finish for fibrous substrates

This invention is directed to a processing approach for the rapid and efficient in-situ polymerization of specially prepared precursor mixtures to achieve near-net-shape production of objects/articles with exact dimensions. The process relies on the use of polymerizable compositions comprised of a mixture of a dead polymer, a reactive plasticizer and, optionally, an initiator, which compositions are semi-solid-like prior to curing and induce low shrinkage upon curing as a result of their partially polymerized nature prior to processing. The partially polymerized nature of the precursor mixtures also allows extremely impact-resistant objects/articles to be fabricated. Other desirable engineering property attributes can similarly be achieved via the judicious blending of starting ingredients in formulating the polymerizable (curable) mixtures.

Near-net-shape polymerization process and materials suitable for use therewith

A method and composition for polymer-reinforced composite cementitious construction materials is described. In one embodiment, a crosslinking component is mixed with a high molecular weight strengthening component and an inorganic cementitious material. The addition of the mixture to water causes a crosslinked molecular network to form within the hydrated, composite cementitious construction material. Both enhanced flexural strength and improved nail-pull resistance are shown, allowing a reduction in weight of the composite cementitious construction material compared to cementitious construction materials made according to other known methods.

Method and composition for polymer-reinforced composite cementitious construction material

This disclosure describes a processing approach for the rapid and efficient in-situ polymerization of specially prepared precursor mixtures to achieve near-net-shape production of objects/articles with exact dimensions. The process relies on the use of polymerizable compositions comprised of a mixture of a reactive plasticizer and an initiator, optionally also including a dead polymer, which compositions are semi-solid-like and induce little shrinkage upon curing as a result of their partially polymerized nature prior to processing. The articles of the invention have a surface and an interior core, the composition of the surface material being distinct from the composition of the core material while at the same time the surface and the core are an integral, monolithic entity. In addition, the articles are dimensionally stable and exhibit high fidelity replication.

Precision integral articles

Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of time so as to move the charged molecules through the medium. The devices although preferably small in size, preferably generate large numbers (100 or more) of electrical fields to a movement area which preferably contains a liquid buffered or gel medium. Mixtures of charged molecules are pulled through the gel by the force of the electrical fields. The fields are preferably activated simultaneously or sequentially one after another at various speeds to create complex force field distributions or moving field waves along the separation medium. Charged molecules capable of moving quickly through the gel will be moved along by the faster moving field waves and be separated from slower moving molecules. The fields can be activated by computer software and can be used to move molecules away from and toward each other to obtain rapid and complex chemical synthesis, sequencing or reaction protocols.

Method for moving charged particles

Construction materials containing surface modified reinforcements are used to fabricate composite structures. The composite structures comprise a matrix material and surface modified reinforcements, such as fibers and particulates. The surface modifier may be applied to a fiber surface using conventional sizing equipment and provides a durable film on the fiber. The surface modifier may be selected to have multifunctional properties, for example, increasing fiber pull-out strength, imparting bio-active properties, improving moisture resistance and other desirable properties to the composite structure.

Construction materials containing surface modified fibers

The present invention is directed to a cryoprotective system that comprises an aqueous solution containing polymeric nano- and micro-particles that exhibit a reversible temperature-dependent volume change. It is also directed to a method for providing cryoprotection to an organism or parts of an organism by pumping the cryoprotective system into the vasculature of the organism prior to exposing the organism to a lower, preferably below 0&#xb0; C., temperature.

Cryoprotective system comprising polymeric nano- or micro-particles

A gypsum-based composite structure is prepared from a slurry comprising a mixture of calcium sulfate hemihydrate, a cellulose ether additive other than CMC and an amount of water that is sufficient to form a slurry. The calcium sulfate hemihydrate is hydrated by the water forming a wallboard core reinforced by the cellulose ether additive. The concentration, viscosity grade and degree of substitution of the cellulose ether are selected to give the composite improved nail pull resistance and greater flexural strength.

Gypsum-based composite materials reinforced by cellulose ethers

Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the crosslinked network. The SPC is isolated and used in many applications.

Molecular compounds having complementary surfaces to targets

The present invention provides an anti-pathogenic air filtration medium comprising a fibrous substrate whose fibers are coated with coating comprising a polymer. The coating provides an environment that is destructive to airborne pathogens. In particular, the filter medium can be used in a building air handling system that both filters the air and eliminates pathogens. The filter medium also can be used to create a new bio-protective gas mask that not only offers protection against chemical warfare agents, but also provides protection against biological pathogens.

Anti-pathogenic air filtration media and air handling devices having protective capabilities against infectious airborne mircoorganisms

The present invention relates to textile treatment compositions for imparting desirable characteristics durably to textile fibers and fabrics, including softness, hydrophobicity, oleophobicity, surface lubricity, abrasion resistance, tear resistance, improved drape, and pilling resistance. More particularly, in one embodiment, the invention is directed to preparations that comprise a carboxylate-functionalized fluorinated polymer and a catalyst that is capable of forming reactive anhydride rings between carboxyl groups on the polymer. In another embodiment, the invention is directed to preparations comprising a polymeric softener having at least one anhydride functional group or at least one reactive group capable of forming an anhydride functional group, together with a catalyst for forming anhydrides from the reactive group or groups. In either embodiment, the resulting reactive anhydride rings bind to substrates, such as textiles and other webs, having free sulfhydryl, alcohol, or amine groups. The invention is further directed to the process for treating textiles and other webs with desirable finishes durable to repeated cleanings. This invention is further directed to the yarns, fibers, fabrics, textiles, finished goods, or nonwovens (encompassed herein under the terms 'textiles' and 'webs') treated with the textile-reactive preparations of the invention. Such textiles and webs exhibit a greatly improved, durable characteristics, such as softness and/or hydrophobicity, even after multiple launderings.

Durable finishes for textiles

The present invention is directed to polymeric treatment preparations for textiles and other fibrous substrates that impart water and oil repellency to fibers, yarns, textiles, or other fibrous substrates. More particularly, this invention comprises an aqueous solution, emulsion or suspension of (a) a fluorinated polymer that contains reactive groups that can complex with metal atoms that have a formal charge of 2 or greater, and (b) one or more metal atoms that have a formal charge of 2 or greater. The invention is further directed to the process for treating fibrous substrates with textile preparations in one step that provide water/soil repellency that is durable to repeated cleanings and to abrasion. This invention is further directed to the yarns, fibers, fabrics, textiles, webs, finished goods, or nonwovens (encompassed herein under the terms 'textiles' and 'fibrous substrates') treated with the textile-reactive water- and soil-resistant preparation of the invention. Such fibrous substrates exhibit a greatly improved, durable water and soil repellency or resistance, even after multiple launderings.

Water-repellent and soil-resistant finish for textiles

A composite structure comprises an inorganic discrete phase, an organic matrix phase and an interfacial layer comprising both the inorganic and organic phases. In one process, the inorganic discrete phase is partially dissolved and the precipitated by a chemical reaction forming an interfacial layer having a finite thickness and transitioning from 100% inorganic to 100% organic.

Mixed organic and inorganic composites with intermingled facial layers

Growing community of inventors

Piedmont, CA, United States of America

David S Soane