Nanocomposix, Inc.

Coronado Aesthetics, LLC

Becton Dickinson and Company Limited

Sienna Biopharmaceuticals, Inc.

Sienna Labs, Inc.

Sebacia, Inc.

David S Sebba

Steven J Oldenburg

Todd James Harris

Dwight Livingston

Mark A Talmer

Robert L Campbell

Thomas D Haubert

Jack H Kessler

Ammon David Lentz

Michael A Brasch

James A Prescott

Alexander George Lastovich

Richard L Moore

Martin Miranda

Michael L Marshall

Gregory S Kramer

Michael Justin Lizzi

William Kevin Carpenter

Scott Nicholas Danhof

Melody M H Kuroda

M Scott Ulrich

Artis R Lockhart

Adam C Curry

Joshua Herr

Owen Lewis Joyce

Kristin Weidemaier

Andrea Liebmann-Vinson

Eric Fallows

Qihua Xu

Randy J Somerville

Kevin G Dolan

Ernie Ritchey

Donald E Gorelick

Miroslaw Bartkowiak

Richard Abbot

Jon E Salomon

Cristian Clavijo

Wendy Dale Woodley

Spencer Lovette

Alexander Adam Papp

Erin Gooch Carruthers

Jeffrey S Ojala

Sean Connell

Shirley Ng

Jack Kessler

Scott N Danhof

Meghan Wolfgang

Martin G Miranda

Eric A Fallows

Melody MH Kuroda

Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

Silver nanoplate compositions and methods

Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples

Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoplates, such as silver nanoplates or silver platelet nanoparticles, and to nanoparticles, solutions and substrates prepared by said methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

Growing community of inventors

Cary, NC, United States of America

David S Sebba