Rutgers, the State University of New Jersey

Merck + Co., Inc.

New Jersey Institute of Technology

Merck Sharp + Dohme Corp.

University of Medicine and Dentistry of New Jersey

Myconostica Ltd

David S Perlin

Steven Park

David W Denning

Rosemarie Kelly

Jennifer Nielsen Kahn

Cameron M Douglas

Stephen A Parent

Arkady Mustaev

Laura Wirpsza

Yanan Zhao

Gregory R Weidman

David Wemyss Denning

Eleusa Maria F Rocha

Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the generaand. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.

Assays for fungal infection

Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the generaandThe methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.

Aptamers having a G-quadruplex structure that bind specifically to the most commonly used azole-class antifungal drugs, biosensors that comprise those aptamers, and invitro methods for determining the level of one of those drugs utilizing those aptamers or biosensors.

Aptamers, biosensors and detection methods for common azole-class antifungal drugs

Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

Assays for resistance to echinocandin-class drugs

The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.

Near infrared label and methods of use thereof

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New York, NY, United States of America

David S Perlin