Wyeth

University of Pennsylvania

American Home Products Corporation

David S Howland

Lioudmila Tchistiakova

Xiang-Yang Tan

Riyez Karim

Margaret Maria Zaleska

Frank S Walsh

Pamela Kelley

Seung Poon Kwak

Menelas N Pangalos

William Kelley, Legal Representative

Jonathan A Bard

Jack Steven Jacobsen

Eileen Marie Kajkowski

Heidi Sofia

Bradley A Ozenberger

Stephen G Walker

Sharon J Rosenzweig-Lipson

Kathleen H Young

Mark Cockett

Karen L Marquis

Erika L F Holzbaur-Howland

Karen Wallace

Nicholas Weber

Erika Lf Holzbaur-Howland

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Method for treating muscle wasting syndrome using antagonist antibodies against GDF-8

Method for treating sarcopenia using antagonist antibodies against GDF-8

Method for treating cachexia using antagonist antibodies against GDF-8

Polynucleotides encoding antagonist antibodies against GDF-8

Method for treating muscular dystrophy using antagonist antibodies against GDF-8

Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8 associated disorders

Antagonist antibodies against GDF-8

A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.

Transgenic animal

Novel proteins which bind human &#x3b2;-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.

&#x3b2;-amyloid peptide-binding proteins and polynucleotides encoding the same

Novel proteins which bind human &bgr;-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.

&bgr;-amyloid peptide-binding proteins and polynucleotides encoding the same

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Yardley, PA, United States of America

David S Howland