Other

Emory University

Buzd, LLC

David S Goldsmith

Gary Stephen Shuster

Jack Arbiser

J Phillip Bowen

Tedman Ehlers

Thomas Philip Robinson

Lorrie Goldsmith

Thomas Phillip Robinson

Louis F LaPorta

Described are surgical hand tools to facilitate the proper implantation beneath the outer layer of ductus to include vessels, the trachea, esophagus, and ureters, as well as glands, organs, or other tissue of medicinal, magnetically susceptible, magnetized, and/or radiation-emitting stays, or ribs—arcuate bands sized in proportion to the substrate structure which incorporate substances for implantation toward the surface of the substrate. Stay insertion tools allow access to and expedite stay insertion into deeper tissue through a small, or 'keyhole' incision at the body surface, eliminating the need for more extensive incision, reducing procedural duration, and can coat each stay with medication and/or an adhesive as each is ejected. Susceptible and magnetized stays allow extraluminal stenting, which avoids the lumen, allowing the in situ treatment of a ductus which malacotic, infected, or otherwise diseased, would likely incur incisions, perforations, and/or abrasions during transluminal treatment.

Stay insertion tools

Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

Ductus side-entry and prosthetic disorder response systems

Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to the section entitled Summary of the Invention.

Integrated system for the infixion and retrieval of implants

Provided is a connector suitable for securely infixing a catheter, electrode, hollow needle, probe, or other styliform device with its tip stabilized within a nontubular anatomical structure. Secure junctions between fluid lines and/or electrodes and tissue are essential for automatic controls and permanent nephrostomies and suprapubic cystostomies, for example, using synthetic materials. These can be made self-contained and fully implanted to treat one chronic condition, or represent but one module controlled as an axis or channel of control in an adaptive ambulatory hierarchical prosthetic disorder response system used to automatically coordinate the treatment of chronic comorbid disease. Such applications require prosthesis-to-native tissue junctions which are secure, immobile, unsusceptible to leaks or microbial intrusion, and require little if any maintenance. Connection for securely and least disruptively merging catheteric and native lumina is described in nonprovisional application Ser. No. 14/121,365, entitled Ductus Side-entry Jackets and Prosthetic Disorder Response Systems, filed on 25 Aug. 2014.

Nonjacketing side-entry connectors and prosthetic disorder response systems

A situational and global context aware calendar, communications, and/or relationship management method and system is disclosed. The system is configured to receive from at least one environmental data gathering device, data about at least one target participant at a gathering of a plurality of participants, analyze such data to determine at least one observed behavior of said target participant, compare said at least one observed behavior against a dataset of at least one behavior; determine when said at least one behavior exceeds a threshold similarity to at least behavior in said dataset; and communicate, to at least one notification device, said at least one observed behavior.

Situational and global context aware calendar, communications, and relationship management

Systems, devices and methods for managing charging and power status for portable devices are disclosed. The systems, devices and methods of the present invention comprise determining existing battery level and charge status of a device, comparing the battery level and charge status with predicted battery usage of tasks associated with calendar events scheduled to take place before the next charge, and transmitting an alert to one or more devices when a threshold likelihood that the battery level will not be sufficient for the predicted battery usage is exceeded. The present invention advantageously displays available power based on time available for certain tasks, and manages device power and resources by modifying and/or transferring tasks from a device having a battery level below a threshold level to one or more other devices with a higher battery levels.

Device power and resource management

Extra-protection fins and pads, and methods of making and using extra-protection fins and pads are disclosed. The extra-protection fins and pads of the present invention comprise a first triangular face, a second triangular face attached and/or connected to the first triangular face at an angle thereby forming a front apex and a top apex, wherein the fins are configured such that the front apex catches and/or absorbs the menstrual and/or other vaginal fluids first, and the extra-protection fin fills backwards toward the top apex, thus preventing unwanted, embarrassing and annoying leakage onto clothing or bedding during periods of heavy flow and/or when lying down. The extra-protection fin may also comprise a third triangular face attached and/or connected to the first and second triangular faces, wherein a vertex of the third triangular face contacts and/or is connected to the first and second triangular faces at the top apex.

Extra-protection pads and related methods

A situational and global context aware calendar, communications, and/or relationship management method and system is disclosed. The system is configured to receive non-calendaring related context information, and, based on that context information, to automatically determine one or more parameters of a meeting request.

Providing recommended meeting parameters based on religious or cultural attributes of meeting invitees obtained from social media data

Global contact synchronization

A system for determining an instruction in a first time limit that can be executed by an executing system is disclosed. The system is configured to request proposed action regarding an event from each of a plurality of operator systems. In some embodiments, the system can calculate a score for each of the proposed actions received from the plurality of operator systems. The system can then automatically determine an instruction in a first time limit based on the calculated scored and command the executing system to execute the instruction.

Decision making using algorithmic or programmatic analysis

The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.

Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states

The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.

The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, incluidng angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.

Growing community of inventors

Atlanta, GA, United States of America

David S Goldsmith