University of Rochester

Southern Research Institute

University of California

The General Hospital Corporation

New York University

David S Goldfarb

Marshall Leedy Stoller

Joseph A Maddry

John R Asplin

Brian H Eisner

Michael Breitenbach

Lynn Rasmussen

Ellie Lucille White

Krister Wennerberg

Marshall L Stoller

John Asplin

Brian Eisner

Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.

Compounds and methods for altering lifespan of eukaryotic organisms

A method for altering the lifespan of a eukaryotic organism. The method comprises the steps of providing a lifespan altering compound, and administering an effective amount of the compound to a eukaryotic organism, such that the lifespan of the organism is altered. In one embodiment, the compound is identified using the DeaD assay.

Method for altering the lifespan of eukaryotic organisms

Recombinant materials, including DNA constructs, expression vectors, and host cells, and methods of identifying an environmental stimulus or a gene that alters the lifespan of an organism are identified. The recombinant DNA constructs include first and second chimeric genes that both encode substantially the same protein that is required for yeast replication, the first chimeric gene containing a promoter responsive to growth medium conditions and the second chimeric gene containing a promoter operable in mother cells but not daughter cells.

Materials and methods for identifying genes and/or agents that alter replicative lifespan

Growing community of inventors

Victor, NY, United States of America

David S Goldfarb