Cerulean Pharma Inc.

Premark Feg L.l.c.

David S Dickey

J Michael Ramstack

John Podobinski

Joseph C Huang

Dana D Herbst

A beater for a mixer includes a shaft including a mixer attachment portion, the shaft defining a rotational axis of the beater. A first stabilizing arm extends outwardly from the shaft and a second stabilizing arm extends outwardly from the shaft and spaced circumferentially from the first stabilizing arm. A first blade has an upper end connected to the first stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end. A second blade has an upper end connected to the second stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end.

Beater for mixing

In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.

Methods and systems for generating nanoparticles

In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent steam.

A beater for a mixer includes a shaft () including a mixer attachment portion (), the shaft defining a rotational axis (A) of the beater. A first stabilizing arm () extends outwardly from the shaft and a second stabilizing arm () extends outwardly from the shaft and spaced circumferentially from the first stabilizing arm. A first blade () has an upper end connected to the first stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face () that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end. A second blade () has an upper end connected to the second stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face () that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end.

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Dayton, OH, United States of America

David S Dickey