Eli Lilly and Company

David S Calnek

Brian W Grinnell

David Thompson Berg

Methods of modulating NF-kB transcription factor

A method of increasing thrombomodulin expression comprising administering to a human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl;

Methods of increasing thrombomodulin expression

A method of increasing thrombomodulin expression comprising administering to a human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof. wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR3## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; and pharmaceutically acceptable salts and solvates thereof. Also encompassed by the invention is a method of inhibiting a thrombotic disorder or event which includes administering to a human in need thereof an effective amount of a compound of formula 1. Also encompassed by the invention is a method of increasing Protein C activation rate which includes the administration of a compound of formula 1.

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Indianapolis, IN, United States of America

David S Calnek