Other

Research Corporation Technologies, Inc.

Medimmune Oncology, Inc.

Cancer Technologies, Inc.

Topical Technologies, Inc.

The University of Arizona

Supergen, Inc

U.S. Bioscience, Inc.

Arizona Board of Regents, a Body Corporate

David S Alberts

Robert T Dorr

Martin Stogniew

Edward H Kaplan

William A Remers

Peter H Bartels

Edward B Skibo

Salah M Sami

Imadul Islam

A method for enhancing production of Vitamin D within a person's skin includes a source of Vitamin D, a sunlight exposure indicator, and a sunscreen. Vitamin D, for example, cod liver oil, is applied to the skin topically via a patch or towlette, or ingested orally. The exposure indicator is worn by the user and changes its state to indicate that the person has been exposed to sunlight for a predetermined period of time. The user preferably waits a sufficient time for the Vitamin D to be absorbed into the skin, and then exposes his or her skin to direct sunlight, and monitors the exposure indicator to determine if it has changed state. The user applies the sunscreen to the user's skin after the exposure indicator changes state.

Method for producing Vitamin D in a person

The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particular, the invention provides a method for treating neurotoxicity and nephrotoxicity associated with the administration of chemotherapeutic agents.

Methods for the treatment of neuro- disorders using aminothiol compounds

Methods for the treatment of nephro-disorders using aminothiol compounds

A method is disclosed for quantitatively measuring the progression of a lesion toward malignant disease by digitizing images of clinical samples of biopsied lesions using a microphotometer that includes a video camera, and a computer that includes a video frame capture board. The digitized image is analyzed to locate the borders of cell nuclei within the captured video image, and one or more chromatin texture features within such nuclei are processed by the computer to arrive at a numerical value. This numerical value is compared to a monotonic progression curve that has been previously established by using the same procedure on known clinical samples ranging from normal tissue to malignant disease. The method can also be used to test the efficacy of chemopreventive drugs and treatments.

Measurement of lesion progression via mapping of chromatin texture features along progression curve

A method for treating palmar-plantar erythrodysethesia syndrome includes applying to affected areas a therapeutically effective amount of a dimethyl sulfoxide solution.

Topical DMSO treatment for palmar-plantar erythrodysethesia

Methods for treatment of neuro--and nephro--disorders and therapeutic

Methods, compositions and a kit for deactivating spills or leaks of HIV infected blood or anticancer drugs by applying to the leak or spill an aqueous solution containing calcium hypochlorite or sodium hypochlorite as the active ingredient. In order to thicken the aqueous solution and thus keep it from spreading beyond its intended area of application, the solution of calcium hypochlorite contains methylcellulose. In addition to chemically deactivating the active anticancer drug, the solution of the invention also effectively decolorizes it, thus preventing permanent stains on any surface or fabric with which the anticancer drug comes into contact.

Method for deactivating a contaminant

A salve includes a water-miscible, hydrophilic cream vehicle, 1-22% by weight a-DFMO, and no absorption enhancer. The salve is preferably contained in an ointment tube permanently sealed at one end to preclude exposure to light and air. The salve is applied as a preventative in an appropriate amount twice daily to skin exposed to actinic radiation. An initial application of a salve including 10% by weight A-DFMO is preferred to minimize the risk of skin irritation without compromising the therapeutic value of the salve. The salve shows no systemic uptake, thereby eliminating systemic toxicities that result from other techniques for administering the drug.

Topical application of .alpha.-DFMO for preventing skin cancer

Method and composition for deactivating HIV infected blood and for

1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents

New cytotoxic quionones, designated amamitosenes and iminoazamitosenes are found to have significant activity against ovarian tumors, colon cancer, myecloma and the like neoplastic diseases. Pharmaceutical preparations and therapeutic regimens utilizing azamitosenes and iminoazamitosenes and their pharmaceutically active derivatives are disclosed.

Antineoplastic compounds and methods of using same

Instrument for measuring tumors

A needle assembly comprises a needle having a sharp point encased within and movable with respect to a sheath having a blunt end. A hub attached to the sheath has a recess therein for receiving a compressible member carried by an end of the needle having a collar thereon for engaging the compressible member. The compressible member retracts the point of the needle into the interior of the sheath to prevent contact of the point by user of the needle. When the needle assembly is attached to a syringe, or other instrument, the collar of the needle is engaged by a portion of the syringe and moved to compress the compressible member and expose the point of the needle for use.

Self-sheathing hypodermic needle

An aspiration device for delivering a controlled dosage of a drug to a smoker's mouth and lungs comprises an elongated container adapted to be positioned within a cigarette or other smoking article adjacent the end intended to be held in the smoker's mouth. The container holds a supply of a drug which is aspirated directly into the smoker's mouth as a result of the suction applied by the smoker to the end of the cigarette. An air inlet port communicates with the outer surface of the cigarette and permits air to enter the container in response to the partial vacuum created by the applied suction. The drug held within the container is discharged through an exit orifice thereof which is coplanar with the end of the cigarette, so that mixing of the drug with the tobacco smoke occurs within the mouth of the smoker, at reduced temperature and lower smoke concentration. By appropriate selection of the size of the exit orifice from the container, the rate at which the drug is delivered can be controlled, so that an amount of drug proportional to the amount of smoke withdrawn from the cigarette or other smoking article can be delivered into the smoker's mouth.

Growing community of inventors

Tucson, AZ, United States of America

David S Alberts