Probiodrug Ag

David Ruiz-Carillo

Stephan Schilling

Jens-Ulrich Rahfeld

Michael Wermann

Christoph Parthier

Milton T Stubbs

Birgit Koch

Hans-Ulrich Demuth

Milton Stubbs

Novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.

Crystal structure of glutaminyl cyclase

A crystal comprising human isoglutaminyl cyclase having a characterized space group of P1211 and unit cell dimensions of +/&#x2212;5% of a=126.51 &#x212b;, b=109.68 &#x212b;, c=159.53 &#x212b;, &#x3b1;=90.0&#xb0;, &#x3b2;=104.9&#xb0; and &#x3b3;=90.0&#xb0;.

Crystal structure of isoglutaminyl cyclase

A novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.

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Singapore, Singapore

David Ruiz-Carillo