Lectec Corporation

Boston Scientific Scimed, Inc.

David Rolf

Elisabeth K Sjoblom Urmann

David A Montecalvo

Daniel M McWhorter

David J Goon

Teri Buseman

James E Lasch

Gordon Kocur

Kasyap Venkata Seethamraju

David H Brandwein

Jane Nichols

Leslie L Block

Dede Cooke

Michael F Shelton

Elisabeth K Urmann

Robert H Michelson

Kasyap Seethamraju

Jim Lasch

Polymers of fluorinated monomers and acrylate and alkyl acrylates are disclosed which demonstrate improved performance as coatings for implantable devices. Such coatings may, for example, be used to release a bioactive agent from the medical device. One specific application lies in drug-eluting coatings for stents.

Fluoropolymer-based medical implant coating compositions

An adhesive patch is provided wherein the patch includes a porous backing having a front side and a back side. The patch also includes a therapeutic formulation located on the front side of the backing. The backing includes a flexible sheet of water insoluble porous material. The therapeutic formulation includes a combination of a antiviral agent useful for treating a viral infection in a mammal (e.g., human), a medicament that relieves topical discomfort, an adhesive, and a solvent. The solvent can preferably include a fragrance.

Treating viral infection at smallpox vaccination site

The present invention provides a water insoluble, protective, adhesive skin patch useful for treating or preventing psoriasis, dermatitis, and/or eczema. The adhesive patch includes a backing that is treated with a sizing agent (e.g., a fluorocarbon solution, a silicone-containing compound, or a combination thereof). The present invention also provides a method for treating or preventing at least one of psoriasis, dermatitis, and eczema in a mammal (e.g., human) and a method for exfoliating the skin surface of a mammal.

Psoriasis patch

The invention provides a mixing and dispensing pouch for applying a wound dressing onto a wound. The pouch includes a pair of superimposed sheets, e.g., of plastic film, connected together at their edges. A pressure-rupturable seal is located between the super-imposed sheets and extends from one edge of the package to the other to form two compartments. The pressure-rupturable seal can be forced open manually by applying pressure on the exterior of the package with the hands so as to increase the hydrostatic pressure in a liquid, e.g., water contained in one compartment of the package causing the seal to rupture and the liquid to spurt through the ruptured seal, mixing with a dry wound dressing contained in the other compartment. If required, additional kneading of the package with the hands will mix the wound dressing for use as soon as it is expelled from the package. The package can be provided with notches to facilitate tearing the package open manually and, if desired, a pour spout with a frangible portion that can be removed so that the fluid dressing can be expelled through the spout.

Mixing and dispensing package for a wound dressing

An adhesive patch is provided wherein the patch includes a flexible backing having a front side and a back side. The patch also includes a therapeutic formulation positioned on and in at least a portion of the front side of the backing such that the therapeutic formulation is partially embedded in at least a portion of the front side of the backing. At least a portion of the backing is treated with a hydrophobic sizing agent such that the portion of the backing that is treated with the hydrophobic sizing agent has a surface energy of about 20 dynes/cm to about 65 dynes/cm . The therapeutic formulation includes a topical acne drug, a solvent that dissolves the topical acne drug, and a pressure sensitive adhesive.

Acne patch

The present invention provides a non-occlusive adhesive skin patch. The patch includes a woven or nonwoven porous backing having a front side and a back side. The patch also includes a therapeutic formulation located on the front side of the backing. The backing includes a flexible sheet of water insoluble porous material. The therapeutic formulation includes a medicament useful for relieving topical discomfort and a pressure sensitive adhesive. The therapeutic formulation optionally includes a solvent that can effectively dissolve the medicament. The present invention also provides a method for alleviating topical discomfort. The method includes applying an adhesive skin patch of the present invention to skin inflicted with a topical disorder.

Antipruritic patch

A solid elastic and pliable self-supporting wound dressing is formed by mixing dry hydrocolloid polymer powder with water. Preferably the dry polymer powder and water are contained in a sealed package having a temporary or manually-removable barrier so that the dry polymer and waster can be stored separately from each other while in the package. The wound dressing may be prepared by breaking or removing the barrier to allow intermixing of the polymer and water within the package so that a fluid, pourable and spreadable aqueous colloidal dispersion is initially formed within the package and which can be removed from the package and easily poured or spread onto the wound. The initially-formed dispersion then solidifies to form a solid or semi-solid elastic, pliable wound dressing containing water and hydrocolloid. The presence of water in the wound dressing provides desirable moisture during the healing process. Preferably the package is made from flexible plastic with a temporary heat-seal barrier between the dry polymer and water. A gelling or crosslinking agent may be also be used to improve the characteristics of some hydrocolloids.

Aqueous gel and package for a wound dressing and method

A non-occlusive medication patch to be applied to the skin includes a porous self-supporting backing layer to give the patch the required integrity and strength by acting as a supporting framework for other components, and a flexible hydrophilic pressure-sensitive adhesive reservoir comprising a natural or synthetic polymer for the sustained release of medication to be absorbed topically through the skin into the body of a patient. The reservoir has two portions: first, an external coating layer with an exposed lower skin-contacting surface that forms a pressure-sensitive bond with the skin, and second, an upper internal portion which infiltrates the porous backing and becomes solidified therein after being applied so that the reservoir and the backing are unified, enabling the backing itself to act as a storage location for the medication-containing reservoir. The medication within the reservoir migrates over time from within the backing through the lower coating layer and passes through the skin to provide sustained release of the medication into the body of a patient.

Method of forming adhesive patch for applying medication to the skin

Adhesive patch for applying medication to the skin and method

A substance countering agent especially for an abused drug or alcohol or a contraceptive agent is contained in a flexible adherent sheet or patch used to achieve the transdermal delivery of the agent through the skin of a person. The patch is limp, fragile, and non-self-supporting. The patch has a weak structure and is sufficiently limp and fragile so that the patch cannot be removed from the skin and later reapplied to the skin as a smooth planar covering. A compliance verification method is also provided for compulsory drug administration. This novel method includes providing a flexible adhesive patch containing a substance countering agent to be administered transdermally to the patient and maintaining the patch sufficiently limp and fragile so that the patch cannot be removed from the skin and later reapplied to the skin as a smooth planar covering. Prior to being applied to the skin, a supporting sheet or carrier is provided for supporting the patch in an outstretched, wrinkle-free condition. The patch is applied to the skin and the supporting sheet or carrier is removed, leaving the patch on the skin as a thin, membranous covering.

Compliance verification method and device in compulsory drug

A vaporizable decongestant is supported and stabilized on a flexible foraminous carrier composed typically of open-cell plastic foam, cloth or other fibrous material such as nonwoven fabric. The term 'foraminous' herein is intended to refer to a substance or medium containing minute openings or perforated by many minute apertures. The decongestant is placed on the surfaces within the interstices and minute apertures or on fibers from which the foraminous carrier is formed. Vaporization of the inhalable decongestant is facilitated by providing the potential for greatly increasing its exposed surface area. Distributing the decongestant composition over the large, expanded surface within the foraminous carrier is beneficial in enhancing both the volatilization and evaporation of the decongestant agent. It also prolongs the useful life of the product. Once vaporized, the aromatic decongestant is available for natural inhalation through the nose or mouth to help relieve one or more of the symptoms of cough, colds, nasal or chest congestion and related symptoms. The foraminous carrier is preferably provided in the form of a patch or sheet that is bonded to the skin to serve as a supporting base for the active decongestant agent. The patch defining the carrier is typically adhesively bonded to the upper part of the body, e.g. on the face, neck or chest, in a location where the decongestant is liberated into the air and can be inhaled through the mouth or nose.

Inhalation therapy decongestant with foraminous carrier

Methods are provided for treating schizophrenia, Tourette's Syndrome, obsessive-compulsive disorder, substance abuse or substance addiction including drug or alcohol addiction, manic-depression syndrome, anexoria or bulimia comprising administering an amount of cotinine or a pharmaceutically acceptable salt thereof, which amount is effective to reduce or alleviate at least one of the symptoms of schizophrenia, Tourette's Syndrome, obsessive-compulsive disorder, substance abuse or substance addiction including drug or alcohol addiction, manic-depression syndrome, anexoria or bulimia in a human or other mammal.

Use of cotinine in treating psychiatric disorders

The invention provides a prepackaged dressing including dry particulate solids for forming a pourable, water-based natural or synthetic hydrocolloidal polyemeric gel to dress wounds. The gel contains a biologically active constituent. Liquid and dry, solid particulate components are separate and are mixed just before use. One dry constituent is the hydrocolloid which is contained in a compartment of a sealed container separate from moisture. After mixing with water, the dry hydrocolloid does not become fully hydrated immediately. The liquid component (water) provides a fluid consistency initially. At this stage, the admixture is sufficiently fluid in consistency to allow it to be poured or spread into a wound. Following application to the wound, the hydrated hydrocolloidal dispersion begins to solidify to form a solid, self-supporting flexible dressing structure consisting primarily of water, the hydrocolloid, as well as the biologically active constituent, e.g., an antibiotic, disinfectant, growth factor or the like in contact with the tissue of the animal or human patient. A gelling or cross-linking agent can also be used advantageously with some of the hydrocolloids. The resulting dressing becomes molded to the shape of the wound and contains a large quantity of moisture that will maintain the wound in a moist condition.

Biologically active aqueous gel wound dressing

A pharmaceutical composition is provided that is useful in treating obsessive-compulsive disorder, Tourette's Syndrome and schizophrenia comprising an amount of cotinine or a pharmaceutically acceptable salt thereof, which amount is effective to reduce or alleviate at least one of the symptoms of Tourette's Syndrome, obsessive-compulsive disorder, or schizophrenia in a human or other mammal.

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Minneapolis, MN, United States of America

David Rolf