Other

Development Finance Corporation of New Zealand

David Roderick Husbands

John Stephen Ayers

The invention relates to a novel sulphated cationic ion exchanger and to a method for preparation thereof. In addition it relates to a method of improving the capacity of an exchange matrix to receive sulphated groups. Although the general attraction of sulphate groups to proteins is known we have found that sulphated ion exchangers selectively bind lipoproteins in blood serum or plasma under suitable conditions. We have also discovered that when hydroxyalkyl groups are introduced into the ion exchanger matrix its capacity for taking up sulphate groups is unexpectedly increased. A method of use of the ion exchanger is also described.

Sulphated ion exchanger and method for preparation thereof

The invention relates to the use of a sulphated ion exchanger to selectively remove lipoproteins from blood plasma or serum. Although the attraction between sulphate groups and proteins has long been recognized it has now unexpectedly been found that cationic ion exchangers whose ion exchange capacity is provided by sulphate groups bind lipoproteins selectively in presence of other plasma or serum proteins and ions when they are equilibrated with solutions containing divalent cations and the same cation is added to the plasma or serum. Types of ion exchanger matrices and applications of the utlity are discussed.

Growing community of inventors

Palmerston North, New Zealand

David Roderick Husbands