Genentech, Inc.

Enyo Pharma

Glaxo Group Limited

David Robert Vesey

Karine Fabienne Malagu

Benjamin Fauber

Benoît De Chassey

Olivier Rene

Paul Colin Michael Winship

Eric Meldrum

Monique Bodil Van Niel

Emanuela Gancia

Stuart Ward

Alberto Gobbi

Paul Winship

Simon Gaines

Tammy Ladduwahetty

Peter J Machin

Mark Stuart Chambers

Calum MacLeod

Benaïssa Boubia

Roberta Lanaro

Christian Montalbetti

Fabrice Guillier

Nicolas Proisy

Calum Macleod

Vincent Derain

Laëtitia Lines

Alan Naylor

Jose Luis Castro Pineiro

Christopher Hurley

Feng Ren

Emmanuel Hubert Demont

Xichen Lin

Qian Liu

Steven James Stanway

Jean-Laurent Paparin

Baowei Zhao

Daryl Simon Walter

Andrew Faller

Peter Henry Milner

David Timothy Macpherson

Jerome Amaudrut

Kevin Meng

Sally Redshaw

Jérôme Amaudrut

The present invention relates to a new class of compounds having an antiviral effect and the uses thereof.

Thiophene derivatives as antiviral agents

The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

Fused thiophene derivatives and their uses

The present invention relates to a new class of compounds of formula (I) having an antiviral effect and the uses thereof.

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X, X, X, X, Y, Z, A, Het, R, R, R, R, RR, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

Aryl sultam derivatives as RORc modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X, X, X, X, Y, Z, A, R, R, R, R, RR, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, n, p, q, r, A, W, X, X, X, X, Y, Z, R, R, R, R, R, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, n, p, q, r, A, W, X, X, X, X, Y, Z, R, R, R, R, R, R, R, R, R, R, R, and Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

1,2,4-oxadiazole indole compounds

The present invention relates to novel hydroxyethylamine compounds having Asp2 (&#x3b2;-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated &#x3b2;-amyloid levels or &#x3b2;-amyloid deposits, particularly Alzheimer's disease.

Hydroxyethylamine derivatives for the treatment of Alzheimer's disease

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Harlow, United Kingdom

David Robert Vesey