Hoffmann-la Roche Inc.

David Richard Parrish

Zoltan George Hajos

John William Scott

Gabriel G Saucy

Leo Berger

Alfred J Corraz

Optically active organic compounds are prepared starting from optically inactive reactants by means of an optically active agent which influences the course of the reaction. In particular optically active compounds having a 'meso' type carbon atom undergo an intramolecular ring closure in the presence of an optically active agent to yield an optically active product having one additional ring. The present process is particularly useful in the preparation of optically active bicyclic diketones which are important intermediates in the total synthesis of steroids.

Substituted-hydroxytetrahydroindanones

A process for the preparation of 6-chloro-.alpha.-methylcarbazole-2-acetic acid from 6-chloro-.alpha.-hydroxy-.alpha.-methylcarbazole-2-acetic acid and/or 6-chloro-.alpha.-methylene-2-carboxylic acid, is described. The preparation of intermediates, such as, 6-chloro-.alpha.-hydroxy-.alpha.-methylcarbazole-2-acetic acid and lower alkyl carbazole-2-oxalate, inter alia, is also described.

Carbazole acetic acid derivatives

Hydroxy methyl carbazole acetic acid and esters

Asymmetric synthesis of organic compounds

The (6-hydroxy-chroman-2-yl) acetic or carboxylic acid derivatives useful as antioxidants and a method for preparing these derivatives from hydroquinones and intermediates in this synthesis as well as the use of these derivatives as intermediates in the preparation of optically active alpha-tocopherol.

Antioxidant chroman compounds

2-Alkyl-2-(3-oxoalkyl)-1,3-cyclopentadiones

Growing community of inventors

Glen Ridge, NJ, United States of America

David Richard Parrish