Assurance Medical, Inc.

Uromed Corporation

David Raymond Widder

Michael A Cundari

Troy William Roberts

Alan Irving West

Brian D Noble

Richard H Theriault

Timothy Last

This invention concerns performing clinical tissue examination with a device that includes sensors which produces signals in response to pressure imposed on the sensors as the sensors are pressed against the tissue. The sensors generate signals in response to pressure imposed on the sensors when pressed against a selected region of tissue. That pressure varies in accordance with properties of underlying tissue structures. An image of the region of tissue is generated based on the signals generated by the sensors. The image is then displayed. The image represents the pressure imposed on the sensors. The image that is displayed may be a three dimensional image of the region of tissue. The signals produced by the sensors can also be processed to detect an underlying tissue structure in the region of tissue. A location or a map of the detected underlying tissue structure relative to a reference point is generated and displayed. The results of a current examination are compared to those of a previous examination.

Clinical tissue examination

A device is provided for diagnosis and treatment of tissue with instruments, specifically locating a tissue structure and positioning an instrument relative to that tissue structure. The device which includes a plurality of sensors for generating signals in response to pressure imposed on the sensors as the sensors are pressed against the tissue. The device which includes a member which is configured to be pressed against tissue and the sensors are disposed on the member, for detection of an underlying tissue structure in the tissue. The device also includes a locating device, arranged at a selected position with respect to the sensors, for indicating a location of the underlying tissue structure. An image based on the sensors may be displayed. The method of using the device includes positioning the locating device, which may be an instrument guide, over an underlying tissue structure based on the image. The method further includes using the locating device to direct an instrument for treating or diagnosing a tissue structure towards that tissue structure.

Diagnosis and treatment of tissue with instruments

A tissue examination device includes a plurality of sensors, each of which produces a signal in response to pressure imposed on the sensor in accordance with the properties of different types of underlying tissue structures as the sensor is pressed against the tissue. A plurality of processing tests are performed on the signals, and the different types of the underlying tissue structures are discriminated from each other based on the results of the tests.

Tissue examination

Methods and devices are described for calibrating the pressure sensors of a tissue examination device to enable the sensors to produce signals that accurately indicate whether an underlying tissue structure is present in tissue being examined. In general, the calibration is performed using a substance configured to apply a selected amount of pressure to the sensors when engaged in a selected way by the tissue examination device. The sensors are calibrated based on levels of the signals produced in response to the selected amount of pressure imposed by the substance. The tissue examination device may be pressed against the substance, or the substance may be pressed against the sensors. Preferably, the substance applies the selected amount of pressure substantially uniformly to the sensors. A wide variety of substances can be used, such as a foam pad, a rubber pad, a gel, a fluid-containing balloon, and pressurized air. The calibration methods and devices are simple to perform--and in fact are preferably performed during device power up so as to be transparent to the user--while accurately compensating for variations in the signals produced by the sensors as a group, as well as for individual (i.e., sensor to sensor) variations.

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Newton, MA, United States of America

David Raymond Widder