Cardiac Pacemakers, Inc.

Boston Scientific Scimed, Inc.

Mayo Foundation for Medical Education and Research

University of Minnesota

Micro-medical Devices, Inc.

David R Wulfman

Joseph T Delaney, Jr

Adeniyi O Aremu

Mary M Byron

Patrick Willoughby

James P Rohl

Danielle Frankson

Martyn G Folan

Thomas M Keating

Martin Hynes

Benjamin J Haasl

Gregory J Sherwood

Douglas Dean Pagoria

Matthew Montague

Joseph Walker

Damien Vincent Nolan

Sarah Melissa Gruba

Joseph A Dearani

Daniel J Foster

Brian Joseph Tischler

Bruce Alan Tockman

Brendan Early Koop

Devon N Arnholt

Mohan Krishnan

Bradley S Swehla

Michael John Kane

Brian L Schmidt

Arthur J Foster

Mark W Boden

Arthur Guy Erdman

Lili Liu

Joel T Eggert

Peter G Edelman

Dana Sachs

Lauren Lydecker

Adam J Rivard

Daniel J Cooke

David A Durand

Christopher R Perrey

Samuel J Asirvatham

David R Holmes, Iii

Timothy A Ostroot

Nicholas Lee Tassoni

James K Cawthra, Jr

Daniel Keith Tomaschko

Shrojalkumar Desai

Adegbola O Adenusi

Andrew J Ro

Niraj Gurung

Adam McGraw

Crystal Marie Anderson-Cunanan

Peter M Pollak

Angelo Fruci

Brian T Berg

Michael Eppihimer

Harold M Burkhart

Sorin V Pislaru

Michael A Felling

David J Smith

Thomas A Wrobel

Justin Robert Alt

Ray McCarthy

Tolga Tas

Kevin E Verzal

Rahul K Rajgarhia

Ulrich A Bonne

David H Jeffrey

Kasyap Venkata Seethamraju

Suraj Kapa

Jeannette C Polkinghorne

David J Lehse

Katherine Lorraine Baldwin

Peter J Schiller

Douglas Pennington

Todd College

Matthew Hein

James A Klos

Diana K Ma

Ronald C McGlennen

Joseph Rausa

Matthew Frost

Matthew Boyer

John D Kroeger

Hoi Ki Ricky Chow

James Aj Holroyd

Pieter Spitael

Kylee M Lersch

Angela K Drexler

David Pettijohn

James A J Holroyd

Jan Seppala

Poorva Rajguru

Christopher Brian Rognrud

Bethanie J H Stadler

Joseph Thomas Delaney, Jr

Jr James K Cawthra

Jr Joseph T Delaney

Adeniyi Aremu

Crystal M Anderson-Cunanan

Ray Mccarthy

A medical device that includes a body and a polymer matrix over the body. The polymer matrix includes a plurality of fibers defining a plurality of pores to permit tissue growth therethrough. The medical device includes a bio-adhesive coating at least partially covering the polymer matrix.

Medical implantable devices and methods of using the same

Compositions including a plurality of particles that may be prepared from a chitosan salt and methods for preparing the same. The plurality of particles may have an average diameter ranging from about 100 μm to about 750 μm, such as from about 150 μm to about 500 μm; a steepness value ranging from about 30 to about 90; and an average aspect ratio greater than 0.6. The plurality of particles may be substantially spherical in shape, for example. Methods of preparation include electrospraying a chitosan salt solution through a needle.

Hemostatic compositions and related methods

Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.

Biocompatible polyisobutylene-fiber composite materials and methods

An example medical device for treating a body lumen is disclosed. The medical device includes an expandable scaffold including first and second regions, each of the first and second regions include a plurality of interstices located therein. The medical device also includes a covering spanning each of the plurality of interstices of the first region. The second region is free of the covering. A biodegradable gripping material is disposed on an outer surface of the covering. Further, the expandable scaffold is configured to shift from a collapsed state to an expanded state and the second region is configured to contact an inner surface of the body lumen in the expanded state. Additionally, the gripping material is designed to initially prevent migration of the expandable scaffold upon implantation in the body lumen until the second region is secured to the inner surface of the body lumen.

Stent including anti-migration capabilities

A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

End-capped polyisobutylene polyurethane

A direct visualization catheter includes an elongate shaft defining a lumen and having a distal end portion and a proximal end portion and a transparent balloon attached to the distal end portion of the shaft. The balloon includes a first layer comprising a thermoset polymer and a plurality of polymeric fibers at least partially embedded in the thermoset polymer and a second layer disposed on the first layer and comprising a hydrogel.

Balloon catheter suturing systems, methods, and devices having pledgets

An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

Durable antimicrobial layer for implantable medical devices

An implantable medical device includes a first component including a first material, a second component including a second material, and a fiber matrix including a plurality of fibers. The fiber matrix joins the first component to the second component. The fiber matrix includes a first a first portion connected to the first component, and a second portion connected to the second component. The first portion of the fiber matrix is interpenetrated with, and mechanically fixed to, the first material. The first portion of the fiber matrix directly contacts the first material.

Fibrous joinery interface between structures

A system may include a leadless cardiac pacing device including a body, a proximal hub, and a helical fixation member opposite the proximal hub; and a first elongate shaft having a lumen extending from a distal end of the elongate shaft proximally into the elongate shaft and a transverse member extending transversely across the lumen. The proximal hub may include a transverse channel extending into the proximal hub, the transverse channel being configured to engage the transverse member.

Tools and systems for implanting and/or retrieving a leadless cardiac pacing device with helix fixation

An implantation and/or retrieval device for a leadless cardiac pacing device may include a first elongate shaft including a lumen; a second elongate shaft slidably disposed within the lumen of the first elongate shaft; an end cap assembly fixedly attached to a distal end of the first elongate shaft; and a plurality of wires attached to the second elongate shaft and extending distally from the end cap assembly, the plurality of wires being movable relative to the end cap assembly. The plurality of wires is configured to engage a proximal hub of the leadless cardiac pacing device. The plurality of wires forms a plurality of wire loops extending distally from the end cap assembly.

A medical device may include a tubular sleeve configured for implantation in a body lumen, the sleeve having a first configuration with a first rigidity and a second configuration with a second rigidity greater than the first rigidity, the sleeve including: a flexible membrane defining an interior lumen; and a channel extending along the membrane.

Deployable sleeves and related methods

A vascular occlusion device for deployment within a lumen of a vessel may include a self-expanding frame configured to shift between a collapsed configuration and an expanded configuration, the self-expanding frame defining a perimeter of an interior space disposed within the self-expanding frame, and an occlusive membrane secured to the self-expanding frame. The occlusive membrane may include a suspended portion disposed within the self-expanding frame and spaced apart from the perimeter of the interior space.

Vascular occlusion device

A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.

Prosthetic heart valves having fiber reinforced leaflets

Growing community of inventors

Minneapolis, MN, United States of America

David R Wulfman