University of Kentucky Research Foundation

Rhode Island Board of Education

Bristol-myers Squibb Compnay

Ceptaris Therapeutics, Inc.

David R Worthen

Peter Anthony Crooks

Kyle Robert Scully

Roberta S King

Martin Stogniew

Robert Alonso

Mark A Pimley

Philip Michael Cocks

Omar A Ghosheh

Aimee K Bence

Simon Crawford Bristow

The invention provides bridged diindole compounds, related pharmaceutical compositions and methods of use thereof, for the prevention, palliation and/or treatment of nervous system disorders.

Diindole compounds useful in treatment of nervous system disorders

Provided are stable compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions.

Stabilized compositions of alkylating agents and methods of using same

Pharmaceutical preparations containing of agmatine, congeners, analogs or derivatives thereof for use in preventing or treating epilepsy, seizures and other electroconvulsive disorders are provided. Embodiments include administering an effective amount of agmatine, an agmatine analog or a pharmaceutically acceptable salt thereof to a human subject in need of treatment or prevention of epilepsy, seizure or other electroconvulsive disorder to treat, reduce, or prevent the disorder in the subject.

Agmatine and agmatine analogs in the treatment of epilepsy, seizure, and electroconvulsive disorders

A method of preparation of crystalline aripiprazole monohydrate includes the use of solution enhanced dispersion by supercritical fluid. Specifically, water is introduced to a stream of supercritical fluid which is then allowed to mix with a stream including a mixture including aripiprazole and a solvent. The mixing results in the substantially simultaneous dispersion and extraction of the aripiprazole from the mixture by the supercritical fluid.

Process of making aripiprazole particles

Nigella sativa derivatives, thymoquinone (TM) and dithymoquinone (DIM) are used in treatment of parental and multi-drug resistant human cancers.

Use of the naturally-occurring quinones thymoquinone and dithymoquinone as antineoplastic and cytotoxic agents

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Wakefield, RI, United States of America

David R Worthen