University of Rochester

Exxonmobil Oil Corporation

Mobil Oil Corporation

Eastman-Kodak Company

Indiana University

University of Houston System

David R Williams

Junzhong Liang

Geun-Young Yoon

Heidi Hofer

Benjamin D Singer

William J Vaughn

Pablo Artal

Alfredo Dubra

Juan Luis Aragon

Pedro Prieto

Fernando Vargas

Antonio Guirao

Jessica Wolfing Morgan

Pang-Chia Lu

Thomas W Martin

Bruce C Campbell

Benoit Ambroise

Raymond A Applegate

Larry N Thibos

Daniel Curtis Gray

Ronald S King

Jo Ann H Squier

Lindsay J Mendes

Daniel Gray

Karen B Perez

Sapna Shroff

James Fienup

Robert Wayne Osgood, Jr

Frederick W Hesser

Walter W Szkapi

David Michael Marotta

A scanning laser ophthalmoscope (SLO) that includes at least one adjustable scanning system adapted for a variable field of view; at least one light source having at least a first spectral emission band suitable to effect at least one of a fluorescence signal and a reflectance signal from a retinal cell; and at least one detector configured to detect at least two different spectral bands from the at least one of the fluorescence and reflectance signals.

Method and apparatus for imaging in an eye

An object to be imaged is illuminated with a structured (e.g., sinusoidal) illumination at a plurality of phase shifts to allow lateral superresolution and axial sectioning in images. When an object is to be imaged in vitro or in another situation in which the phase shifts cannot be accurately determined a priori, the images are taken, and the phase shifts are estimated a posteriori from peaks in the Fourier transforms. The technique is extended to the imaging of fluorescent and non-fluorescent objects as well as stationary and non-stationary objects.

Structured illumination for imaging of stationary and non-stationary, fluorescent and non-fluorescent, objects

A method for in vivo imaging of at least one cell including: first obtaining a first image of at least one cell; second obtaining a second image of the at least one cell; adjusting at least one of the first image and the second image to account for a movement of the at least one cell; generating a final image based at least in part on the adjusting.

A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which may be used to control a compensating optical or wavefront compensation device such as a deformable mirror. It may also be used to fabricate a contact lens or intraocular lens, or to guide a surgical procedure to correct the aberrations of the eye. Any of these methods could correct aberrations beyond defocus and astigmatism, allowing improved vision and improved imaging of the inside of the eye.

Method and apparatus for improving vision and the resolution of retinal images

Several metrics to predict the subjective impact of the eye's wavefront aberrations are presented. The metrics can be based on RMS wavefront errors or slopes, the area of the critical pupil, a curvature parameter, the point spread function, the optical transfer function, or the like. Other techniques include the fitting of a sphero-cylindrical surface, the use of multivariate metrics, and customization of the metric for patient characteristics such as age.

Metrics to predict subjective impact of eye's wave aberration

A vision metric, called the sharpness metric, indicates the subjective sharpness of a patient's vision by taking into account both the wavefront aberration and the retinal response to the image. A retinal image quality function such as the point spread function is convolved by a neural quality function, and the maximum of the convolution over the retinal plane provides the sharpness metric. The sharpness metric can be used to control eye surgery or the fabrication of a lens.

Sharpness metric for vision quality

The present invention relates to oriented or hot-blown shrink films which may be manufactured from by a number of processes. The oriented films may be manufactured by double bubble, LISIM, tape bubble, trapped bubble or tenter framing processes. The films of the present invention are useful as a shrink film to package and label a variety of products. The films exhibit a high degree of MD shrinkage in a very controlled and consistent manner while providing a number of other positive characteristics such as optical clarity, puncture and abrasion resistance, controlled gauge, and superior web winding and handling characteristics. The shrink control layers of the films of the present invention contain a modifier component selected from plastomers and/or metallocene catalyzed ethylene-propylene copolymers and blends thereof.

Heat-shrinkable polymeric films

A wavefront aberration of an eye is determined, e.g., in real time. The eye is illuminated, and the light reflected from the retina is converted into spots with a device such as a Hartmann-Shack detector. The displacement of each spot from where it would be in the absence of aberration allows calculation of the aberration. Each spot is located by an iterative technique in which a corresponding centroid is located in a box drawn on the image data, a smaller box is defined around the centroid, the centroid is located in the smaller box, and so on. The wavefront aberration is calculated from the centroid locations by using a matrix in which unusable data can be eliminated simply by eliminating rows of the matrix. Aberrations for different pupil sizes are handled in data taken for a single pupil size by renormalization.

Rapid, automatic measurement of the eye's wave aberration

A thermoplastic film label composite that includes an outer skin layer that has a printable, untreated, cavitated surface which may be utilized for printing and affixing the label to a substrate. The invention further provides a film label composite printed on both its front- and back-side, and a method of manufacturing the same.

Thermoplastic film label composite with a printable, untreated, cavitated surface

Ocular refraction is determined from wavefront aberration data, and an optimum customized correction is designed. The eye's wave aberration is measured by using a detector such as a Shack-Hartmann detector. From the aberration, an image metric is calculated, and the second-order aberrations which optimize that metric are determined. From that optimization, the refractive correction required for the eye is determined. The image metric is one of several metrics indicating the quality of the image on the retinal plane or a proxy for such a metric. The required refractive correction can be used to form a lens or to control eye surgery. If it is possible to detect more aberrations than can be corrected, those aberrations are corrected which most affect vision, or for which the eye's error tolerance is lowest.

Determination of ocular refraction from wavefront aberration data and design of optimum customized correction

A method for improving the visual performance of a person involves correcting higher-order monochromatic aberrations in combination with the correction of chromatic aberration. Such correction results in a visual benefit greater than that realized by correcting only the higher-order monochromatic aberrations or the chromatic aberration alone. The higher-order monochromatic aberrations are corrected by introducing appropriate phase profiles to compensate for the wavefront aberrations of the eye. This compensation can be provided by contact lenses, IOLs, inlays and onlays having appropriate surface shapes or by corneal shaping achieved through refractive surgery or other techniques. Chromatic aberration can be corrected by spectral filtering or artificial apodization. An apodization filter is described that provides a non-uniform amplitude transmission across the pupil of the eye. Contact lenses or other ocular devices for correcting higher-order monochromatic aberrations may include an appropriate apodization filter for correcting chromatic aberration, or an external optical device for correcting chromatic aberration may be used in combination with a contact lens, etc. for correcting the higher-order monochromatic aberrations. A device and method for improved retinal imaging is also described.

Apparatus and method for improving vision and retinal imaging

A uniaxially heat-shrinkable, biaxially oriented, multilayer film having a polypropylene containing core layer and at least one high density polyethylene containing skin layer adjacent the core layer. The core layer contains isotactic polypropylene and a modifier which reduces the crystallization or crystallinity of the polypropylene by increasing chain imperfections or reducing isotacticity of the polypropylene resin. Examples of materials which are useful as modifiers include atactic polypropylene, syndiotactic polypropylene, ethylene-propylene-butene-1 terpolymer, polybutene-1, and linear low density polyethylene.

Uniaxially shrinkable biaxially oriented polypropylene film with HDPE skin

Growing community of inventors

Fairport, NY, United States of America

David R Williams